From the Research
Providencia rettgeri in a blood culture indicates a serious bloodstream infection that requires prompt antibiotic treatment, and the recommended treatment should be guided by antimicrobial susceptibility testing due to its potential resistance to multiple antibiotics. The choice of antibiotic should be based on the most recent and highest quality study, which in this case is 1, a 2024 study that highlights the importance of prompt identification and appropriate antibiotic therapy for P. rettgeri infections.
Key Considerations
- P. rettgeri is a rare cause of nosocomial infection, but it can lead to high rates of morbidity and mortality if not treated promptly and effectively 2.
- The bacterium is capable of producing biofilms and is intrinsically resistant to commonly used antibiotics, making treatment challenging 2.
- Antimicrobial susceptibility testing is crucial in guiding the choice of antibiotic, as P. rettgeri can develop resistance to multiple antibiotics 1, 3.
- Supportive care with IV fluids and close monitoring of vital signs is essential in managing the infection.
Treatment Options
- A carbapenem such as meropenem or ertapenem may be effective, but the choice should be guided by antimicrobial susceptibility testing 1.
- Alternative options such as piperacillin-tazobactam may also be considered, depending on the susceptibility pattern of the isolate 1.
- Phage therapy, using lytic phages such as vB_PreS_PR1, may be a potential alternative treatment option for antibiotic-resistant P. rettgeri infections 4.
Prevention and Control
- Identifying and controlling the source of infection is critical in preventing the spread of P. rettgeri 2.
- Contact isolation and use of sterile gloves after each patient contact can help prevent the spread of the infection 2.
- Evaluating patients for predisposing factors such as diabetes, recent hospitalization, or indwelling medical devices can help identify those at high risk of developing P. rettgeri infections 1.