From the Research
The standard diclofenac suppository dose for adults is 50-100 mg inserted rectally 1-2 times daily, with a maximum daily dose of 150 mg. For children, dosing is weight-based: typically 1-3 mg/kg/day divided into 2-3 doses, not exceeding the adult maximum. Suppositories should be inserted after bowel movements when possible, and patients should remain lying down for a few minutes after insertion. Diclofenac suppositories are particularly useful for patients who cannot take oral medications, have gastrointestinal issues, or need rapid pain relief. The rectal route bypasses first-pass metabolism in the liver, allowing for faster absorption and potentially fewer gastrointestinal side effects compared to oral administration. However, patients should be aware of possible side effects including rectal irritation, bleeding risk (especially in those on blood thinners), and the standard NSAID risks of kidney injury, cardiovascular events, and gastrointestinal complications. Diclofenac suppositories should be stored at room temperature and protected from light.
Key Considerations
- The most recent and highest quality study 1 provides evidence on the use of NSAIDs, including diclofenac, for acute renal colic, but does not specifically address suppository dosing.
- Other studies 2, 3, 4, 5 provide information on the efficacy and safety of diclofenac in various formulations, but the rectal suppository dose is not explicitly mentioned.
- The recommended dose is based on general guidelines and clinical practice, as the provided evidence does not directly address the specific question of diclofenac suppository dosing.
Potential Risks and Benefits
- Patients should be aware of the potential risks of NSAID use, including gastrointestinal complications, kidney injury, and cardiovascular events.
- The rectal route of administration may reduce the risk of gastrointestinal side effects compared to oral administration.
- Diclofenac suppositories may be a useful option for patients who cannot take oral medications or need rapid pain relief.