From the FDA Drug Label
Trazodone Hydrochloride Tablets should be swallowed whole or broken in half along the score line. Trazodone Hydrochloride Tablets can be swallowed whole or administered as a half tablet by breaking the tablet along the score line.
Trazodone tablets can be cut in half along the score line, as indicated in the drug label 1 and 1.
From the Research
Trazodone tablets can generally be cut in half, especially the scored tablets which are designed with a line to facilitate splitting, but it is crucial to consult with a healthcare provider or pharmacist first, particularly for extended-release formulations which should never be cut 2. When considering cutting trazodone tablets, it's essential to understand the formulation of the specific trazodone product being used. The most recent and highest quality study available does not directly address the issue of cutting trazodone tablets, but it emphasizes the importance of proper administration and dosing to ensure efficacy and minimize side effects 3. Key points to consider when deciding to cut trazodone tablets include:
- The formulation of the trazodone product: Extended-release formulations should not be cut as this can disrupt the controlled-release mechanism and potentially cause too much medication to be released at once.
- The presence of a score line on the tablet: Scored tablets are designed to be split, but it's still important to use a pill cutter for accuracy.
- The need for dosage adjustment: Cutting tablets may be necessary when adjusting dosages or starting with a lower dose to minimize side effects.
- Consultation with a healthcare provider or pharmacist: Before splitting any prescription medication, it's crucial to confirm that this is appropriate for the specific formulation and treatment plan. Some studies have investigated the properties and utility of trazodone in multiple disorders, including its use as a hypnotic for psychotropic-induced or other insomnias, but these do not directly address the issue of cutting tablets 2, 4. In terms of safety and efficacy, trazodone has been found to be an effective antidepressant with a relatively low incidence of serious adverse effects, but its use requires careful consideration of individual patient needs and monitoring for potential side effects 3, 5, 6.