Recommended Dosage of Magnesium L-Threonate
The recommended dosage of magnesium L-threonate is one capsule daily (approximately 2 grams), preferably taken on an empty stomach. 1
Dosage Information
Magnesium L-threonate (Magtein®) is a specific form of magnesium that has been developed to enhance brain bioavailability of magnesium. The dosing recommendations are:
- Standard dose: 1 capsule daily (2 grams) 1
- Clinical study dose: 2 grams/day has been shown effective in improving cognitive function 2
- Maximum tested dose: Up to 3 grams daily has been evaluated for safety 3
Benefits and Mechanisms
Magnesium L-threonate has several unique properties compared to other magnesium formulations:
- It effectively raises magnesium levels in the brain and neurons 2
- Studies show it may improve memory and cognitive functions 2
- It has demonstrated neuroprotective effects in animal models of neurological disorders 4, 5
Special Considerations
- Bioavailability: Magnesium L-threonate has superior brain bioavailability compared to other magnesium supplements 5
- Composition: A typical dose provides approximately 250 mg of elemental magnesium and 2730 mg of L-threonate 3
- Safety: The European Food Safety Authority has concluded that magnesium L-threonate is safe at the recommended dosages 3
Potential Contraindications
While specific contraindications for magnesium L-threonate are not extensively documented, general magnesium supplementation precautions should be observed:
- Renal impairment: Patients with significant renal insufficiency should avoid magnesium supplements due to risk of hypermagnesemia 6
- Cardiac conditions: Patients with cardiac conditions should be monitored for ECG changes, AV nodal conduction block, and bradycardia 6
- Medication interactions: Magnesium supplements may interact with certain medications 6
Monitoring
For those taking magnesium L-threonate regularly:
- Baseline serum magnesium levels should be checked before starting therapy
- Follow-up serum magnesium levels should be checked 1-2 weeks after initiation
- Periodic monitoring (every 3-6 months) is recommended for long-term supplementation 6
Clinical Evidence
Research supports that magnesium L-threonate at 2 grams daily can improve memory and cognitive function in healthy adults 2. This dosage has been shown to be effective in clinical studies and is consistent with the FDA-approved labeling 1, 2.
Human studies have demonstrated that this dosage is both safe and effective for improving cognitive performance, particularly in older adults 2.