From the Research
Bactrim (sulfamethoxazole/trimethoprim) and Farxiga (dapagliflozin) can be taken together, but caution is advised due to potential interactions, particularly in patients with pre-existing kidney issues, as both medications can affect kidney function 1. When taking these medications concurrently, patients should monitor for signs of dehydration, electrolyte imbalances, and kidney function changes.
Key Considerations
- Bactrim is an antibiotic used to treat various infections, while Farxiga is an SGLT2 inhibitor used for diabetes management.
- Both medications can affect kidney function—Bactrim may increase potassium levels and Farxiga works by increasing glucose excretion through the kidneys.
- Patients should maintain adequate hydration while taking these medications together, especially in hot weather or during illness.
- Regular monitoring of kidney function is recommended, particularly in older adults or those with existing kidney issues.
Potential Risks and Benefits
- The combination of Bactrim and Farxiga may increase the risk of kidney damage or worsening kidney function, especially in patients with pre-existing kidney disease 2.
- However, Farxiga has been shown to slow the decline in kidney function in patients with chronic kidney disease, with or without type 2 diabetes 1, 2.
- Patients should be aware of the potential benefits and risks of taking these medications together and should discuss their individual situation with their healthcare provider.
Recommendations
- Patients taking Bactrim and Farxiga together should be closely monitored for signs of kidney damage or worsening kidney function.
- Healthcare providers should consider alternative antibiotic options for patients with pre-existing kidney issues or those taking Farxiga.
- Patients should be educated on the importance of maintaining adequate hydration and monitoring for signs of dehydration, electrolyte imbalances, and kidney function changes while taking these medications together.