From the FDA Drug Label
TRINTELLIX may cause serious side effects, including: Serotonin syndrome. Increased risk of bleeding. Manic episodes. Discontinuation syndrome. Eye problems (angle-closure glaucoma) Low levels of sodium in your blood (hyponatremia). Sexual problems (dysfunction). The most common side effects of TRINTELLIX include nausea, constipation, and vomiting.
The side effects of Trintellix (vortioxetine) include:
- Serious side effects:
- Serotonin syndrome
- Increased risk of bleeding
- Manic episodes
- Discontinuation syndrome
- Eye problems (angle-closure glaucoma)
- Low levels of sodium in your blood (hyponatremia)
- Sexual problems (dysfunction)
- Common side effects:
- Nausea
- Constipation
- Vomiting 1
From the Research
Trintellix (vortioxetine) commonly causes nausea as its most frequent side effect, affecting about 8.9% of patients, especially when starting treatment, as reported in the most recent and highest quality study 2.
Common Side Effects
Other common side effects of Trintellix include:
- Dizziness
- Constipation
- Vomiting
- Dry mouth
- Sexual dysfunction Some patients may also experience headaches, diarrhea, or unusual dreams.
Serious Side Effects
Serious but rare side effects of Trintellix include:
- Serotonin syndrome (confusion, rapid heart rate, high fever)
- Allergic reactions
- Abnormal bleeding
- Low sodium levels
- Increased risk of suicidal thoughts, particularly in young adults and adolescents
Management of Side Effects
Most side effects tend to diminish within the first few weeks of treatment as the body adjusts to the medication. Taking Trintellix with food can help reduce nausea. If severe or persistent side effects occur, patients should contact their healthcare provider rather than stopping the medication abruptly, as discontinuation can cause withdrawal symptoms like dizziness, irritability, and flu-like symptoms.
Mechanism of Action
Trintellix works by modulating serotonin receptors and inhibiting serotonin reuptake in the brain, which explains many of these side effects, as noted in a study on its pharmacological profile 3.
Real-World Effectiveness and Safety
A recent systematic review and meta-analysis found that Trintellix is effective, well-tolerated, and safe for treating major depressive disorder in clinical practice, with significant improvements observed in depressive severity, cognitive function, and functioning 2.