Rheumatoid Arthritis (RA): Morning hand swelling is a common symptom of RA, an autoimmune disorder that causes inflammation and pain in the joints. The swelling is often accompanied by stiffness and can significantly impact daily activities.

Osteoarthritis: Although more commonly associated with wear and tear, osteoarthritis can cause morning stiffness and swelling, especially in the hands, due to inflammation and fluid accumulation overnight.
Gout: Gouty arthritis can cause sudden, severe swelling and pain in the hands, especially after periods of rest or at night, due to urate crystal deposition.
Psoriatic Arthritis: This condition combines the swollen, scaly skin of psoriasis with joint pain and arthritis, which can include morning hand swelling.

Infection (e.g., Cellulitis or Abscess): Infections can cause rapid swelling, redness, and warmth, and it's crucial to identify and treat them promptly to avoid serious complications.
Deep Vein Thrombosis (DVT): Although less common in the hands, DVT can cause swelling and should be considered, especially if there's a history of clotting disorders or recent immobility.
Compartment Syndrome: A medical emergency where increased pressure within a muscle compartment can lead to nerve and muscle damage, characterized by severe pain, swelling, and sometimes pallor or paresthesia.

Sarcoidosis: A condition that can cause inflammation in various parts of the body, including the hands, leading to swelling and other symptoms.
Amyloidosis: A group of diseases that can cause abnormal protein deposits in various organs, including the hands, leading to swelling among other symptoms.
Hematologic Disorders (e.g., Hemophilia): Certain bleeding disorders can lead to joint swelling due to hemorrhage into the joint space, though hand involvement is less common than larger joints.