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Last updated: September 29, 2025View editorial policy

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Differential Diagnosis for Eyes Burning

  • Single most likely diagnosis
    • Dry eye syndrome: This is a common condition that can cause a burning sensation in the eyes due to inadequate tear production or poor tear quality.
  • Other Likely diagnoses
    • Allergies: Seasonal or environmental allergies can cause eye irritation, leading to a burning sensation.
    • Conjunctivitis (pink eye): This is an inflammation or infection of the outer membrane of the eyeball and the inner eyelid, which can cause burning, itching, and redness.
    • Blepharitis: Inflammation of the eyelids can cause burning, itching, and redness of the eyes.
    • Contact lens irritation: Improper use or poor fit of contact lenses can lead to eye irritation and a burning sensation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Chemical burns: Exposure to chemicals can cause severe eye damage and a burning sensation, requiring immediate medical attention.
    • Angle-closure glaucoma: A medical emergency that can cause severe eye pain, burning, and vision loss if not treated promptly.
    • Orbital cellulitis: A bacterial infection of the tissues surrounding the eye, which can cause severe pain, burning, and vision loss if left untreated.
  • Rare diagnoses
    • Sjögren's syndrome: An autoimmune disorder that can cause dry eyes and mouth, leading to a burning sensation in the eyes.
    • Thyroid ophthalmopathy: A condition associated with Graves' disease that can cause eye irritation, burning, and protrusion of the eyeballs.
    • Trachoma: A rare infectious disease caused by the bacterium Chlamydia trachomatis, which can cause eye irritation, burning, and vision loss if left untreated.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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