From the Research
Levothyroxine Liquid Formulations
- The brand name for levothyroxine liquid is Tirosint SOL, as mentioned in the study 1.
- Tirosint SOL is a new formulation of liquid levothyroxine that gained FDA approval in 2017 1.
- This formulation is manufactured as LT4 solution in purified water and glycerol, making it an attractive option due to the lack of alcohol content 1.
Clinical Utility of Liquid Levothyroxine
- Liquid levothyroxine has been shown to be more effective than tablet formulation in patients with malabsorption caused by interfering diseases, drugs, and bariatric surgery 1.
- The better pharmacokinetics of liquid levothyroxine has also been confirmed in subjects without malabsorption, including patients on replacement or suppressive therapy 1.
- Liquid levothyroxine appears to be equally effective whether taken before or during breakfast 1.
Comparison with Other Formulations
- Liquid levothyroxine and soft gel capsules have been shown to be more active than tablet levothyroxine in controlling thyroid-stimulating hormone (TSH) in hypothyroid patients with gastric disorders, malabsorption, or drug interference 2.
- However, the evidence in favor of using liquid levothyroxine or soft gel capsules over traditional tablets is weak, and additional studies are needed to investigate the potential benefits and cost-effectiveness 3.