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Last updated: September 29, 2025View editorial policy

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Differential Diagnosis for a Cold Foot

  • Single most likely diagnosis:
    • Peripheral artery disease (PAD): This condition is characterized by the narrowing or blockage of the blood vessels outside of the heart, leading to reduced blood flow to the limbs, which can cause a cold foot.
  • Other Likely diagnoses:
    • Poor circulation: This can be due to various factors such as smoking, diabetes, or prolonged periods of inactivity, leading to decreased blood flow to the foot.
    • Raynaud's phenomenon: A condition that affects blood flow to the fingers and toes, and sometimes the ears, nose, and lips, causing them to turn blue or white in response to cold or stress.
    • Hypothyroidism: An underactive thyroid gland can cause decreased circulation and cold intolerance, leading to cold feet.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Deep vein thrombosis (DVT): A blood clot in the deep veins of the leg can cause decreased circulation and lead to a cold foot, and if dislodged, can be life-threatening.
    • Frostbite: Prolonged exposure to cold temperatures can cause damage to the skin and underlying tissues, leading to a cold foot.
    • Aortic occlusion: A blockage of the aorta, the main artery that supplies blood to the body, can cause decreased blood flow to the lower limbs, leading to cold feet.
  • Rare diagnoses:
    • Buerger's disease: A rare disease of the arteries and veins in the arms and legs, which can cause decreased blood flow and lead to cold feet.
    • Erythromelalgia: A rare disorder that causes burning pain, heat, and redness in the hands and feet, and can also cause cold feet in some cases.
    • Complex regional pain syndrome (CRPS): A chronic pain condition that can cause changes in skin temperature, including cold feet.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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