What causes peeling of the skin on the hands of an 8-year-old female?

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Last updated: March 19, 2025 • View editorial policy

Differential Diagnosis for Peeling Hands in an 8-Year-Old Female

  • Single Most Likely Diagnosis + Kawasaki Disease: Although more commonly associated with fever, rash, and lymphadenopathy, Kawasaki disease can cause peeling of the skin on the hands and feet during its subacute phase. It's a leading cause of acquired heart disease in children, making it a critical consideration.
  • Other Likely Diagnoses + Eczema (Atopic Dermatitis): Can cause dryness and peeling of the skin, especially if not properly managed. It's common in children and can be exacerbated by environmental factors. + Psoriasis: Although less common in children, psoriasis can cause skin peeling. It often presents with well-demarcated, erythematous plaques. + Contact Dermatitis: An allergic reaction or irritation from substances like soap, detergent, or certain plants can lead to peeling skin on the hands.
  • Do Not Miss Diagnoses + Staphylococcal Scalded Skin Syndrome (SSSS): A serious condition caused by staphylococcal toxins that can lead to widespread skin peeling. It's life-threatening and requires immediate medical attention. + Toxic Epidermal Necrolysis (TEN): A severe skin condition usually triggered by medications, leading to skin peeling and detachment. It's a medical emergency. + Autoimmune Disorders (e.g., Pemphigus): Rare in children, but conditions like pemphigus can cause blistering and peeling of the skin.
  • Rare Diagnoses + Netherton Syndrome: A rare genetic disorder characterized by ichthyosiform dermatitis, hair shaft abnormalities, and an increased susceptibility to atopic diseases. + Keratolytic Winter Erythema: A rare condition causing peeling of the skin on the palms and soles, often associated with cold weather. + Peeling Skin Syndrome: A group of rare genetic disorders characterized by continuous shedding of the outer layer of the skin.

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