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Last updated: September 29, 2025View editorial policy

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Differential Diagnosis for Vulva Burning and Irritation

Single Most Likely Diagnosis

  • Vulvovaginal candidiasis: This is a common condition caused by a yeast infection, leading to symptoms such as vulvar burning, itching, and irritation. It's often associated with a white, cottage cheese-like discharge.

Other Likely Diagnoses

  • Contact dermatitis: An allergic reaction or irritation from soaps, detergents, or other products can cause vulvar burning and irritation.
  • Vulvar lichen sclerosus: A chronic skin condition that can cause itching, burning, and pain in the vulvar area, often associated with white, patchy skin changes.
  • Urinary tract infection (UTI): While primarily affecting the urinary system, UTIs can cause discomfort and burning sensations in the vulvar area, especially during urination.
  • Vulvodynia: A condition characterized by chronic pain, burning, or discomfort in the vulva without an identifiable cause.

Do Not Miss Diagnoses

  • Herpes simplex virus (HSV): Although less common, genital herpes can cause severe vulvar burning and irritation, along with vesicles or ulcers. Missing this diagnosis could lead to complications and the risk of transmission.
  • Squamous cell carcinoma of the vulva: A rare but serious condition where vulvar burning and irritation could be symptoms of an underlying malignancy. Early detection is crucial for effective treatment.
  • Lichen planus: An autoimmune condition that can affect the vulva, causing burning, itching, and pain. It's essential to diagnose and treat to prevent long-term complications.

Rare Diagnoses

  • Vulvar intraepithelial neoplasia (VIN): A precancerous condition that can cause vulvar burning and irritation. It's less common but important to identify to prevent progression to invasive cancer.
  • Paget's disease of the vulva: A rare form of vulvar cancer that can present with burning, itching, and a visible rash or lesion.
  • Zinc deficiency: Although rare, a severe zinc deficiency can cause skin lesions and discomfort, including vulvar burning and irritation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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