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Last updated: September 30, 2025View editorial policy

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Differential Diagnosis for Penis Pain

  • Single most likely diagnosis
    • Phimosis or paraphimosis: This condition is characterized by the inability to retract the foreskin (phimosis) or the foreskin getting stuck behind the glans penis (paraphimosis), leading to pain and swelling. It's a common issue that can cause significant discomfort and is often seen in clinical practice.
  • Other Likely diagnoses
    • Balanitis: An inflammation of the glans penis, often caused by poor hygiene, infections (bacterial, fungal, or viral), or allergic reactions. It presents with pain, redness, and swelling.
    • Urinary tract infection (UTI): While more common in women, men can also experience UTIs, which can cause pain in the penis, especially during urination.
    • Epididymitis: An inflammation of the epididymis, a tube at the back of the testicle that stores and carries sperm. It can cause pain in the testicles, penis, and groin area.
    • Peyronie's disease: A condition characterized by the development of scar tissue inside the penis, leading to curved, painful erections.
  • Do Not Miss diagnoses
    • Testicular torsion: A medical emergency where the spermatic cord becomes twisted, cutting off the blood supply to the testicle. It can cause severe pain in the testicle and penis and requires immediate attention.
    • Penile fracture: A rupture of the tunica albuginea, the fibrous layer surrounding the corpora cavernosa, often occurring during vigorous sexual activity. It's a painful condition that requires prompt medical intervention.
    • Penile cancer: Although rare, penile cancer can cause pain, especially if it progresses and invades surrounding tissues.
  • Rare diagnoses
    • Priapism: A condition where the penis remains erect for hours, causing pain and discomfort. It can be caused by certain medications, medical conditions, or unknown reasons.
    • Penile thrombosis: A blood clot in the penis, which can cause pain and swelling. It's a rare condition but can be associated with significant morbidity if not treated promptly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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