Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 30, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Generalized Mid to Lower Abdominal Pain Radiating to Back Pain

Single Most Likely Diagnosis

  • Nephrolithiasis (Kidney Stones): This condition often presents with severe, crampy pain that starts in the flank or lower back and radiates to the lower abdomen or groin. The pain can be accompanied by nausea, vomiting, and urinary frequency or urgency.

Other Likely Diagnoses

  • Pyelonephritis: An infection of the kidney, which can cause flank pain that radiates to the lower abdomen and is often accompanied by fever, chills, and urinary symptoms.
  • Diverticulitis: Inflammation of the diverticula in the colon, which can cause lower abdominal pain that may radiate to the back, accompanied by changes in bowel habits and possible fever.
  • Appendicitis: Although classically presenting with right lower quadrant pain, some cases can have a more generalized or mid-abdominal pain that radiates to the back, especially if the appendix is retrocecal.
  • Gastroenteritis: Inflammation of the stomach and intestines, usually due to infection, which can cause generalized abdominal pain that may radiate to the back, along with nausea, vomiting, and diarrhea.

Do Not Miss Diagnoses

  • Abdominal Aortic Aneurysm (AAA): A potentially life-threatening condition where the aorta enlarges, which can cause severe back or abdominal pain. It's crucial to consider this diagnosis, especially in older patients with risk factors such as smoking or hypertension.
  • Pancreatitis: Inflammation of the pancreas, which can cause severe, persistent pain in the upper abdomen that radiates to the back, often accompanied by nausea and vomiting.
  • Ectopic Pregnancy: A pregnancy that develops outside the uterus, which can cause lower abdominal pain that may radiate to the back, along with vaginal bleeding and missed periods. This is a critical diagnosis to consider in women of childbearing age.
  • Ovarian Torsion: A condition where the ovary twists around its ligaments, cutting off blood supply, which can cause severe, sudden lower abdominal pain that may radiate to the back.

Rare Diagnoses

  • Intestinal Obstruction: A blockage that prevents normal flow of the products of digestion, which can cause severe abdominal pain that may radiate to the back, along with nausea, vomiting, and constipation.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis, which can cause chronic abdominal pain that may radiate to the back, along with changes in bowel habits and possible weight loss.
  • Primary or Metastatic Tumors: Abdominal or back pain can be a symptom of various cancers, such as pancreatic, ovarian, or colon cancer, which are less common but important to consider, especially with persistent or worsening symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.