From the Research
Bioidentical Bi-EST 5.0 Estrogen Menopause Relief Cream is not recommended for use in males as it is specifically formulated for women experiencing menopausal symptoms. This cream contains a combination of estradiol and estriol at a 5.0 mg/g concentration, designed to address female hormonal imbalances. Males who use this product may experience feminizing effects including breast development (gynecomastia), reduced muscle mass, decreased libido, erectile dysfunction, and potential mood changes. The male endocrine system naturally produces much lower levels of estrogen than females, and introducing high doses of external estrogens disrupts this balance. Additionally, estrogen therapy in males has been associated with increased risks of cardiovascular issues, blood clots, and certain cancers, as suggested by studies on hormone therapy in men 1.
Some studies have evaluated the effects of bioidentical hormone therapy in women, but there is limited evidence on its use in men. A 2016 Cochrane review found that bioidentical hormone therapy was effective in reducing hot flushes in women, but the quality of the evidence was low to moderate, and there was no good evidence of a difference in effectiveness between bioidentical hormone therapy and conventional hormone therapy 2.
The use of compounded bioidentical hormone therapy is concerning due to the lack of evidence to support its safety and efficacy, as highlighted by the 2020 National Academies of Sciences, Engineering, and Medicine recommendations 3. If a male is experiencing hormonal concerns, they should consult with an endocrinologist or urologist who can properly evaluate testosterone levels and other relevant hormones, and prescribe appropriate treatments specifically designed for male physiology rather than using products formulated for female menopause.
Key points to consider:
- Bioidentical Bi-EST 5.0 Estrogen Menopause Relief Cream is not intended for use in males
- Estrogen therapy in males can cause feminizing effects and increase the risk of cardiovascular issues, blood clots, and certain cancers
- There is limited evidence on the use of bioidentical hormone therapy in men
- Compounded bioidentical hormone therapy is not recommended due to the lack of evidence to support its safety and efficacy
- Males with hormonal concerns should consult with an endocrinologist or urologist for proper evaluation and treatment.