What is the initial workup for knee pain?

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Initial Workup for Knee Pain

Radiography is the initial imaging study recommended for evaluating chronic knee pain, with a minimum of two views (anteroposterior and lateral) of the affected knee. 1

Clinical Evaluation Components

History - Focus on:

  • Age (patients >55 years have higher risk of fracture and osteoarthritis)
  • Location, onset, duration, and quality of pain
  • Mechanical symptoms (locking, catching, giving way)
  • History of trauma or injury
  • Swelling patterns
  • Previous knee problems or surgeries
  • Associated systemic symptoms

Physical Examination - Systematic approach:

  • Inspection for deformity, swelling, erythema
  • Palpation for tenderness, effusion, warmth
  • Range of motion assessment
  • Strength testing
  • Neurovascular evaluation
  • Special tests:
    • McMurray test (specific but not sensitive for meniscal tears) 2
    • Lachman test (more sensitive and specific than drawer sign for ACL tears) 2
    • Assessment of joint line tenderness (sensitive but not specific for meniscal tears) 2

Imaging Algorithm

  1. Initial Imaging: Plain Radiographs

    • Should include at least one frontal projection (anteroposterior, Rosenberg, or tunnel view), a tangential patellar view, and a lateral view 1
    • Provides quick, cost-effective identification of fractures, degenerative changes, osteochondral defects, and effusions 3
    • Reserve for chronic knee pain (>6 weeks) or acute traumatic pain meeting specific criteria 4
  2. When Initial Radiographs Are Normal or Show Joint Effusion:

    • MRI without contrast is usually the appropriate next step if symptoms persist 1
    • MRI has near 100% sensitivity for fracture detection and excellent capability for detecting bone marrow contusions, occult fractures, and soft tissue injuries 5
  3. When Trauma Is Present - Ottawa Knee Rules: Consider radiographs if any of the following are present:

    • Age >55 years
    • Tenderness at head of fibula or patella
    • Inability to bear weight for 4 steps
    • Inability to flex knee to 90 degrees 2

Special Considerations

When to Consider Alternative Imaging:

  • CT Scanning: When better delineation of fractures is needed or when MRI is contraindicated 5, 3
  • MRI: When soft tissue injuries (meniscal, ligamentous) are suspected and surgery is being contemplated 3
  • Radiography of Hip or Lumbar Spine: When knee radiographs are unremarkable and there is clinical concern for referred pain 1

Red Flags Requiring Urgent Evaluation:

  • Severe pain, swelling, and instability after acute trauma
  • Inability to bear weight
  • Signs of joint infection (fever, erythema, limited range of motion) 4

Common Pitfalls to Avoid

  1. Premature MRI: Approximately 20% of patients with chronic knee pain have MRI without recent radiographs, which may be unnecessary 1

  2. Missing Referred Pain: Knee pain may originate from hip or lumbar spine pathology, requiring appropriate imaging of these areas when knee radiographs are normal 1

  3. Overreliance on Imaging: Clinical features (age >50 years, morning stiffness <30 minutes, crepitus, bony enlargement) are 89% sensitive and 88% specific for underlying chronic arthritis, often making additional imaging unnecessary 2

  4. Failure to Apply Ottawa Knee Rules: These evidence-based criteria help determine when radiographs are necessary for suspected fractures, avoiding unnecessary imaging 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Evaluation of acute knee pain in primary care.

Annals of internal medicine, 2003

Research

The painful knee: choosing the right imaging test.

Cleveland Clinic journal of medicine, 2008

Guideline

Imaging Guidelines for Patella Fractures

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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