Cefdinir Dosing Recommendations
For adults, the recommended dose of cefdinir is 300 mg twice daily or 600 mg once daily. For children, the recommended dose is 14 mg/kg/day divided into one or two doses (maximum 600 mg/day). 1
Adult Dosing
- Standard adult dose: 300 mg twice daily or 600 mg once daily
- Duration: Typically 5-10 days depending on infection type
- Maximum daily dose: 600 mg
Pediatric Dosing
- Standard pediatric dose: 14 mg/kg/day divided into one or two doses
- Maximum daily dose: 600 mg
- Administration options:
- Once-daily regimen: 14 mg/kg given as a single dose
- Twice-daily regimen: 7 mg/kg given every 12 hours
Dosing Considerations by Age and Weight
While specific cefdinir dosing for neonates isn't provided in the evidence, it's important to note that cefdinir is generally not recommended for infants under 6 months of age due to limited safety and efficacy data.
Dosing by Indication
Cefdinir is effective for treating various infections with the same standard dosing:
- Respiratory tract infections
- Skin and skin structure infections
- Acute otitis media
- Sinusitis
- Pharyngitis/tonsillitis
Special Considerations
- Renal impairment: Dose adjustment required for patients with creatinine clearance <30 mL/min
- Administration with food: Can be taken with or without food; however, iron supplements, iron-fortified foods, or antacids containing aluminum or magnesium may reduce absorption
Clinical Efficacy
Cefdinir has demonstrated good clinical and bacteriological efficacy against common pathogens in respiratory tract and skin infections 2. Its broad spectrum of activity makes it particularly useful in areas with high rates of beta-lactamase production in common pathogens 1.
Common Side Effects
- Diarrhea (most common, approximately 20%)
- Loose stools
- Rash
Practical Considerations
- Cefdinir oral suspension has demonstrated superior taste and palatability compared to other oral antimicrobial agents, which may improve adherence, especially in pediatric patients 1
- The convenient once- or twice-daily dosing schedule may improve patient compliance compared to medications requiring more frequent administration
Potential Pitfalls
- Avoid using in patients with known cephalosporin allergy
- Be aware of potential cross-reactivity in patients with penicillin allergy (approximately 10%)
- Consider local resistance patterns when prescribing, particularly for respiratory pathogens
Cefdinir's pharmacokinetic profile allows for convenient once- or twice-daily dosing, making it an excellent option for treating mild to moderate bacterial infections in both adults and children, particularly in outpatient settings.