From the Research
At 7 weeks of gestation, a progesterone level below 16.5 ng/mL is considered low and may be associated with a higher risk of miscarriage. Progesterone is crucial during early pregnancy as it maintains the uterine lining, supports embryo implantation, and prevents uterine contractions that could lead to miscarriage. By 7 weeks, the placenta is beginning to take over progesterone production from the corpus luteum, and levels should be rising steadily. Low progesterone at this stage may indicate a non-viable pregnancy, ectopic pregnancy, or threatened miscarriage.
Key Points to Consider
- A study published in 2023 1 found that a progesterone concentration of ≥16.5 ng/mL at pregnancy test day was associated with higher ongoing pregnancy rate and live birth rate.
- The same study suggested that women with progesterone levels <16.5 ng/mL may benefit from individualized prolonged luteal phase support.
- Progesterone supplementation may be recommended for women with low progesterone levels, typically in the form of vaginal suppositories, vaginal gel, or oral micronized progesterone.
- Regular monitoring through blood tests is essential to track progesterone levels and pregnancy viability.
Important Considerations
- The decision to supplement progesterone should be based on individual clinical assessment, as not all cases of low progesterone require intervention.
- The optimal progesterone level during early pregnancy may vary depending on individual factors, such as the presence of multiple gestations or a history of recurrent miscarriage.
- Further research is needed to determine the optimal progesterone level and supplementation strategy for women at risk of miscarriage or other pregnancy complications.