Differential Diagnosis for Tongue Blisters
- Single Most Likely Diagnosis
- Aphthous ulcers (canker sores): These are the most common cause of tongue blisters, characterized by small, painful, and recurrent ulcers that can appear on the tongue and other parts of the mouth.
- Other Likely Diagnoses
- Oral herpes (HSV-1): This viral infection can cause painful blisters on the tongue, lips, and other parts of the mouth.
- Trauma: Accidental biting of the tongue or other forms of trauma can lead to the formation of blisters.
- Allergic reactions: Allergies to certain foods, medications, or substances can cause tongue blisters.
- Nutritional deficiencies: Deficiencies in vitamins such as B12 or iron can lead to oral changes, including tongue blisters.
- Do Not Miss Diagnoses
- Erythema multiforme: A severe skin and mucous membrane disorder that can cause blisters on the tongue and other parts of the body, often triggered by infections or medications.
- Stevens-Johnson syndrome: A life-threatening condition that can cause blisters on the tongue, lips, and other parts of the body, often triggered by medications or infections.
- Oral cancer: Although rare, tongue blisters can be a symptom of oral cancer, making it essential to rule out this diagnosis.
- Rare Diagnoses
- Pemphigus vulgaris: A rare autoimmune disorder that can cause blisters on the tongue and other parts of the mouth.
- Behçet's disease: A rare condition that can cause oral ulcers, including tongue blisters, as well as other systemic symptoms.
- Geographic tongue: A rare condition characterized by the appearance of irregularly shaped, smooth, red patches on the tongue, which can sometimes be mistaken for blisters.