What is another name for fosinopril-HCTZ (fosinopril sodium and hydrochlorothiazide)?

Alternative Names for Fosinopril-HCTZ

Fosinopril sodium and hydrochlorothiazide is also known as Monopril-HCT, which is the brand name for this fixed-dose combination medication.

This combination medication consists of two active ingredients:

1. Fosinopril sodium - an angiotensin-converting enzyme (ACE) inhibitor
2. Hydrochlorothiazide (HCTZ) - a thiazide diuretic

Clinical Information About This Combination

This fixed-dose combination is used in the management of hypertension, where:

• Fosinopril works by inhibiting the renin-angiotensin system, reducing vasoconstriction and sodium retention 1
• HCTZ complements this action by increasing sodium and water excretion through the kidneys

Dosage Information

The typical dosage forms available include:

• Initial dose: 10 mg fosinopril/12.5 mg HCTZ
• Target dose: 20-40 mg fosinopril/12.5-25 mg HCTZ 1, 2

Clinical Considerations

• This combination provides synergistic antihypertensive effects, as demonstrated in clinical studies 2
• The dual route of elimination of fosinoprilat (the active metabolite of fosinopril) through both hepatic and renal pathways makes it particularly useful in patients with moderate renal impairment 3
• Unlike some other ACE inhibitors that require dose adjustment in renal impairment, fosinopril may not require dosage modifications due to its compensatory elimination pathway 3

Important Precautions

• ACE inhibitors including fosinopril are contraindicated in pregnancy 4
• Monitor serum potassium and renal function within 3 months of starting this combination 4
• If eGFR is <30 mL/min/m², a loop diuretic should be considered instead of HCTZ 1

This fixed-dose combination represents an effective option for hypertension management, particularly in patients who require multiple agents to achieve blood pressure control.