Differential Diagnosis for Sudden Stoppage of Regular Menstrual Cycle

Single Most Likely Diagnosis

• Pregnancy: This is the most common cause of sudden stoppage of regular menstrual cycle, as it is a physiological state where menstruation ceases due to hormonal changes.

Other Likely Diagnoses

• Polycystic Ovary Syndrome (PCOS): A hormonal disorder that can cause irregular or absent menstrual periods due to ovulation problems.
• Thyroid Disorders: Both hyperthyroidism and hypothyroidism can affect menstrual regularity by disrupting the balance of hormones necessary for ovulation and menstruation.
• Stress and Weight Changes: Significant stress or changes in weight can affect the hypothalamic-pituitary-adrenal axis, leading to changes in menstrual cycle regularity.
• Birth Control Methods: Certain birth control methods, especially those that are hormonal, can cause changes in menstrual bleeding patterns, including cessation.

Do Not Miss Diagnoses

• Pituitary Tumors: Although rare, tumors of the pituitary gland can disrupt hormone production, leading to menstrual irregularities or cessation. Missing this diagnosis could lead to serious health consequences, including vision loss and hormonal imbalances.
• Premature Ovarian Failure (POF): Also known as premature ovarian insufficiency, this condition leads to the loss of function of the ovaries before the age of 40, resulting in cessation of menstruation.
• Eating Disorders: Conditions like anorexia nervosa can lead to significant weight loss and hormonal imbalances, causing menstrual cessation. Early detection is crucial for effective management and prevention of long-term health consequences.

Rare Diagnoses

• Asherman's Syndrome: A rare condition characterized by the formation of adhesions or scar tissue in the uterus, which can lead to menstrual cessation or significant reduction in menstrual flow.
• Congenital Adrenal Hyperplasia: A group of inherited disorders that affect the adrenal glands, potentially leading to hormonal imbalances that can disrupt menstrual cycles.
• Sheehan Syndrome: A rare condition that occurs in some women who experience severe blood loss during childbirth, leading to pituitary gland damage and subsequent hormonal deficiencies, including those necessary for menstruation.