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Differential Diagnosis for Unexplained Weight Loss

Single Most Likely Diagnosis

  • Depression: Unexplained weight loss is a common symptom of depression, which can lead to changes in appetite and eating habits, resulting in weight loss.

Other Likely Diagnoses

  • Diabetes Mellitus: Uncontrolled diabetes can cause weight loss due to the body's inability to use glucose for energy, leading to the breakdown of fat and muscle for fuel.
  • Hyperthyroidism: An overactive thyroid gland can increase metabolism, leading to weight loss despite increased appetite.
  • Chronic Infections (e.g., tuberculosis, HIV): Chronic infections can cause weight loss due to increased metabolic rate, decreased appetite, and malabsorption.
  • Gastrointestinal Disorders (e.g., celiac disease, Crohn's disease): Malabsorption and chronic inflammation can lead to weight loss.

Do Not Miss Diagnoses

  • Cancer: Various types of cancer (e.g., pancreatic, lung, stomach) can cause unexplained weight loss due to tumor effects, metabolic changes, and decreased appetite.
  • HIV/AIDS: Weight loss is a common symptom of HIV/AIDS, particularly in the later stages of the disease.
  • Addison's Disease: Adrenal insufficiency can cause weight loss, fatigue, and other symptoms.

Rare Diagnoses

  • Pheochromocytoma: A rare tumor of the adrenal gland that can cause weight loss, hypertension, and other symptoms.
  • Whipple's Disease: A rare bacterial infection that can cause weight loss, diarrhea, and other gastrointestinal symptoms.
  • Amyloidosis: A rare condition characterized by the deposition of abnormal proteins in various organs, leading to weight loss and other symptoms.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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