Differential Diagnosis for Numbness and Tingling when Sleeping

• Single most likely diagnosis
  • Carpal Tunnel Syndrome: This condition is a common cause of numbness and tingling, especially in the hands, and can be exacerbated by sleeping positions that put pressure on the wrists.
• Other Likely diagnoses
  • Ulnar Neuropathy: Compression or damage to the ulnar nerve can cause numbness and tingling in the hands, particularly affecting the little and ring fingers.
  • Radiculopathy: Compression or irritation of the nerve roots in the spine can lead to numbness and tingling in various parts of the body, depending on the affected nerve root.
  • Peripheral Neuropathy: Damage to the peripheral nerves can cause numbness, tingling, and pain, often in the hands and feet.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Multiple Sclerosis: An autoimmune disease that affects the brain and spinal cord, leading to a wide range of neurological symptoms, including numbness and tingling.
  • Spinal Cord Compression: Compression of the spinal cord can cause numbness, tingling, and weakness, and if not treated promptly, can lead to permanent damage.
  • Stroke or Transient Ischemic Attack (TIA): Although less common, numbness and tingling can be symptoms of a stroke or TIA, especially if accompanied by other symptoms like facial weakness or difficulty speaking.
• Rare diagnoses
  • Vitamin Deficiency (e.g., Vitamin B12 deficiency): Certain vitamin deficiencies can cause neurological symptoms, including numbness and tingling.
  • Lyme Disease: A bacterial infection that can cause neurological symptoms, including numbness and tingling, especially if left untreated.
  • Sarcoidosis: A condition that can cause inflammation and damage to various parts of the body, including the nerves, leading to numbness and tingling.