Recommended Dosing for Chymoral Forte Tablets
The recommended dosing for Chymoral Forte (alpha-chymotrypsin) tablets is 6 drops orally 4 times a day for patients aged 2 years to adult. 1
Dosage Information
Chymoral Forte is an enzymatic preparation containing alpha-chymotrypsin, which has anti-inflammatory properties. The FDA-approved labeling provides clear guidance on the appropriate dosing:
- Standard dosage: 6 drops orally 4 times daily
- Age range: Suitable for patients from 2 years of age through adulthood
- Administration: Should be taken orally
Clinical Applications
Chymoral Forte has been studied in various clinical scenarios:
- Burn patients: Research has shown that Chymoral Forte can modulate cytokine levels (IL-6 and IL-1beta) in burn patients, potentially regulating the severity of the inflammatory phase 2
- Musculoskeletal conditions: Some evidence suggests potential benefit in inflammatory conditions, though clinical significance may be limited 3
- Acute-phase protein modulation: The preparation has demonstrated effects on acute-phase proteins following burn injury, reflecting potential anti-inflammatory activity 4
Important Considerations
When prescribing Chymoral Forte, clinicians should be aware of:
- Limited robust evidence: While the medication has an established dosing protocol, high-quality evidence for efficacy in many conditions is limited
- Primary mechanism: Works through proteolytic enzyme activity to potentially reduce inflammation
- Monitoring: No specific monitoring parameters are required, but clinical response should be assessed
Potential Pitfalls
- Overestimating efficacy: One study examining Chymoral in lumbar disc prolapse found its value to be "little better than placebo" despite some improvements in straight-leg raising and reduced analgesic requirements 3
- Drug interactions: As with any proteolytic enzyme, potential interactions with anticoagulants or antiplatelet medications should be considered, though specific data for Chymoral Forte is limited
- Expecting immediate results: The anti-inflammatory effects may take time to develop, as suggested by studies showing changes in inflammatory markers over several days 4
While Chymoral Forte has been studied in specific clinical scenarios like burn management, clinicians should maintain realistic expectations about its efficacy and follow the recommended dosing of 6 drops orally 4 times daily.