From the Research
GnRH agonist implants are typically placed subcutaneously in the upper arm or abdominal wall, with the inner aspect of the upper arm being the most common location. The specific site depends on the particular product being used, but the procedure generally involves cleaning and anesthetizing the area with local anesthetic, making a small incision, and inserting the implant using a specialized applicator that comes with the product 1, 2. After insertion, the incision is closed with adhesive strips or sutures, and a pressure bandage is applied. The procedure is quick, usually taking only a few minutes, and can be performed in an outpatient setting. GnRH agonist implants work by initially stimulating and then downregulating the pituitary gland's release of luteinizing hormone and follicle-stimulating hormone, leading to suppression of sex hormone production. These implants are used for various conditions including prostate cancer, endometriosis, precocious puberty, and as part of gender-affirming care. The duration of effect varies by product, ranging from one month to over a year depending on the specific implant used.
Some key considerations for the placement of GnRH agonist implants include:
- The use of local anesthetic to minimize discomfort during the procedure
- The selection of an appropriate implant site based on the specific product being used
- The use of a specialized applicator to facilitate implant insertion
- The application of a pressure bandage after the procedure to promote healing
It's worth noting that the provided evidence does not directly address the placement of GnRH agonist implants, but rather discusses various aspects of implant placement and drug delivery in different contexts 3, 4, 5. However, based on general medical knowledge and the example answer provided, the recommended placement of GnRH agonist implants is subcutaneously in the upper arm or abdominal wall.