How many Lisinopril tablets should be taken daily for a 30-day period?

Lisinopril Dosage Calculation

For the prescription of Lisinopril 40 MG Tablet with instructions to take one (1) tablet by mouth every morning and one half (1/2) tablet every evening, the patient should take 1.5 tablets daily for a total of 45 tablets for a 30-day period. 1

Dosage Breakdown

• Morning dose: 1 tablet (40 mg) 1
• Evening dose: 1/2 tablet (20 mg) 1
• Total daily dose: 1.5 tablets (60 mg) 1
• Monthly requirement: 1.5 tablets × 30 days = 45 tablets 1

Clinical Context

This dosing regimen aligns with FDA-approved guidelines for Lisinopril in heart failure management:

• The recommended dosage range for heart failure is 5-40 mg once daily 1
• The maximum recommended dose is 40 mg daily 1, 2
• The prescribed regimen (60 mg total daily) exceeds the standard maximum dose, which may be appropriate in certain clinical situations but requires careful monitoring 2

Important Considerations

• The split dosing (morning and evening) is not standard for Lisinopril, which typically has a long enough half-life (12.6 hours) to be administered once daily 3, 4
• This divided dosing may be intended to:
  • Improve tolerability 5
  • Provide more consistent 24-hour blood pressure control 4
  • Reduce risk of adverse effects from a single large dose 2

Dispensing Calculation

• Prescription quantity: 30 tablets 1
• Daily requirement: 1.5 tablets 1
• Days supply: 30 tablets ÷ 1.5 tablets/day = 20 days 1
• For a full 30-day supply: 45 tablets would be needed 1

Clinical Monitoring

• Monitor for hypotension, especially in patients also taking diuretics 2, 1
• Check renal function and potassium levels within 1-2 weeks of therapy initiation 2
• Assess for common side effects including dizziness, cough, and hyperkalemia 2, 1