From the FDA Drug Label
The empirical formula for rosuvastatin calcium is (C 22H 27FN 3O 6S) 2Ca Rosuvastatin tablets, USP for oral use contain rosuvastatin 5 mg, 10 mg, 20 mg, or 40 mg (equivalent to 5.2 mg, 10.4 mg, 20. 8 mg, and 41.6 mg rosuvastatin calcium, USP) Each tablet contains: ... dibasic calcium phosphate dihydrate, ... Active ingredient:rosuvastatin as rosuvastatin calcium, USP (amorphous) Inactive ingredients:... dibasic calcium phosphate dihydrate, ...
Yes, Crestor (Rosuvastatin) contains calcium, in the form of rosuvastatin calcium and dibasic calcium phosphate dihydrate. 1, 2, 3
From the Research
Composition of Crestor (Rosuvastatin)
- Crestor, also known as Rosuvastatin, is a medication that belongs to the "statins" group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor 4.
- The chemical name of Rosuvastatin is Rosuvastatin calcium (ROS), indicating that it contains calcium 4, 5.
Pharmaceutical Formulations
- Rosuvastatin calcium is used in various pharmaceutical formulations, including directly compressed tablets that offer hydrotropic and micellar solubilization for improved dissolution rate and extent of drug release 5.
- The formulations may include excipients such as caffeine and Soluplus® to enhance the dissolution rate and maintain a concentration of the drug that exceeds its solubility 5.
Chemical Properties
- Rosuvastatin has a high affinity for the active site of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and exhibits greater potency in inhibiting enzyme activity and cholesterol synthesis in vitro than other statins 6.
- The effects of rosuvastatin are selective for hepatic cells, and there is minimal uptake of the drug by nonhepatic tissues 6.
Calcium Channel Blocking Activity
- Statins, including rosuvastatin, have been shown to exhibit calcium channel blocking activity through voltage-gated channels, which may contribute to their side effects such as muscle weakness and gastrointestinal disorders 7.