Ceftum CV (Cefuroxime and Clavulanic Acid) Dosage and Treatment Protocol
For Ceftum CV (Cefuroxime and Clavulanic Acid), the recommended adult dosage is 500 mg twice daily for most infections, with treatment duration of 7-14 days depending on the infection type and severity. 1
General Dosing Information
Adult Dosing
- Standard adult dose: 500 mg twice daily 1
- For more severe infections: 500 mg every 8 hours or 750-1000 mg twice daily 1
- For respiratory tract infections: 250-500 mg twice daily depending on severity 1
- For urinary tract infections: 250 mg twice daily may be sufficient for uncomplicated cases 1
Pediatric Dosing
- Children: 20-30 mg/kg/day divided into two doses 1
- For more severe infections in children: 30-40 mg/kg/day divided into two doses 1
- Maximum pediatric dose should not exceed adult dosing 1
Treatment Duration by Infection Type
- Respiratory tract infections: 7-10 days 1
- Urinary tract infections: 7-14 days 1
- Skin and soft tissue infections: 7-10 days 1
- Otitis media: 5-10 days (5 days may be sufficient in uncomplicated cases) 1, 2
- Sinusitis: 7-10 days (some studies show 5 days may be effective for cefuroxime axetil) 1
Administration Guidelines
- Should be taken with food to enhance absorption 3, 4
- The clavulanic acid component helps overcome resistance from beta-lactamase producing organisms 1
- Tablets should be swallowed whole, not crushed or chewed 3
- For patients unable to take oral medications, consider parenteral therapy until oral intake is possible 1
Special Populations
Renal Impairment
- Dose adjustment required for patients with creatinine clearance <30 ml/min 2
- For severe renal impairment, consider reducing dose or extending dosing interval 4
Hepatic Impairment
- No specific dose adjustment required for mild to moderate hepatic impairment 4
- Monitor closely in severe hepatic disease 2
Clinical Considerations and Cautions
- Assess for hypersensitivity to cephalosporins or penicillins before initiating therapy 1
- Common adverse effects include gastrointestinal disturbances (diarrhea, nausea, vomiting) 3, 4
- Monitor for superinfection, especially with prolonged use 2
- For sequential therapy (IV to oral), parenteral cefuroxime can be switched to oral cefuroxime axetil once clinical improvement is observed 4, 2
Indications for Ceftum CV
- Upper respiratory tract infections (sinusitis, pharyngitis, otitis media) 1
- Lower respiratory tract infections (bronchitis, pneumonia) 1, 2
- Urinary tract infections 1
- Skin and soft tissue infections 1, 3
- Early Lyme disease 4, 2
Antimicrobial Spectrum
- Effective against beta-lactamase producing strains of Haemophilus influenzae and Moraxella catarrhalis 3, 4
- Active against Streptococcus pneumoniae (including penicillin-intermediate strains) 4, 2
- Covers most common respiratory and urinary tract pathogens 3, 2
- Not effective against MRSA or Pseudomonas species 4, 5