Differential Diagnosis for Sudden Foot Drop
Single Most Likely Diagnosis
- Peroneal nerve palsy: This is the most common cause of foot drop, resulting from compression or injury to the peroneal nerve, which controls the muscles responsible for lifting the foot.
Other Likely Diagnoses
- L5 radiculopathy: Compression or injury to the L5 nerve root can cause foot drop, as this nerve root supplies the muscles involved in foot dorsiflexion.
- Stroke or cerebral vasculature accident (CVA): Although less common, a stroke can cause foot drop if the area of the brain controlling the lower extremities is affected.
- Muscular dystrophy: Certain types of muscular dystrophy, such as Duchenne muscular dystrophy, can lead to foot drop due to progressive muscle weakness.
Do Not Miss Diagnoses
- Cauda equina syndrome: A serious condition caused by compression of the nerve roots in the lower spine, which can lead to foot drop, among other symptoms. Prompt diagnosis and treatment are crucial to prevent permanent damage.
- Spinal cord infarction: A rare but potentially devastating condition where the blood supply to the spinal cord is interrupted, leading to sudden onset of neurological deficits, including foot drop.
- Tumor or cyst compressing the peroneal nerve or nerve roots: Although less common, a tumor or cyst can compress the nerves, leading to foot drop.
Rare Diagnoses
- Charcot-Marie-Tooth disease: A group of inherited disorders that affect the peripheral nerves, leading to progressive muscle weakness and atrophy, which can cause foot drop.
- Guillain-Barré syndrome: A rare autoimmune disorder where the body's immune system attacks the peripheral nerves, leading to muscle weakness and potentially foot drop.
- Diabetic amyotrophy: A condition associated with diabetes that affects the nerves, leading to muscle weakness and wasting, which can cause foot drop.