Recommended Dilution Rate for Monocef (Ceftriaxone)
For intravenous administration of Monocef (Ceftriaxone), reconstitute with appropriate diluent to achieve a concentration between 10 mg/mL and 40 mg/mL, with 100 mg/mL being the standard concentration after initial reconstitution. 1
Reconstitution Guidelines
Initial Reconstitution
For IV administration, reconstitute vials with appropriate IV diluent according to the following table 1:
- 250 mg vial: add 2.4 mL diluent
- 500 mg vial: add 4.8 mL diluent
- 1 gram vial: add 9.6 mL diluent
- 2 gram vial: add 19.2 mL diluent
After initial reconstitution, each 1 mL of solution contains approximately 100 mg of ceftriaxone 1
Administration Method
- Administer intravenously by infusion over 30 minutes in adults and children 1
- For neonates, administer over 60 minutes to reduce the risk of bilirubin encephalopathy 1
Compatible Diluents
- Appropriate IV diluents include 1:
- Sterile Water for Injection
- 0.9% Sodium Chloride Solution
- 5% Dextrose Solution
Important Compatibility Warnings
Do not use diluents containing calcium (such as Ringer's solution or Hartmann's solution) to reconstitute ceftriaxone or to further dilute for IV administration as particulate formation can result 1
Ceftriaxone is incompatible with the following medications in admixtures 1:
- Vancomycin
- Amsacrine
- Aminoglycosides
- Fluconazole
When any of these drugs need to be administered with ceftriaxone, administer them sequentially with thorough flushing of IV lines between administrations 1
Stability After Reconstitution
- Reconstituted ceftriaxone solutions remain stable (less than 10% loss of potency) for the following time periods 1:
- At 100 mg/mL concentration:
- Room temperature (25°C): 2 days
- Refrigerated (4°C): 10 days
- At 250-350 mg/mL concentration:
- Room temperature (25°C): 24 hours
- Refrigerated (4°C): 3 days
- At 100 mg/mL concentration:
Special Considerations
- The color of reconstituted solutions ranges from light yellow to amber, depending on storage time, concentration, and diluent used 1
- After reconstitution, protection from light is not necessary 1
- Ceftriaxone has been shown to be compatible with metronidazole hydrochloride at concentrations not exceeding 5-7.5 mg/mL metronidazole with ceftriaxone 10 mg/mL 1
Following these dilution guidelines will ensure proper administration of Monocef (Ceftriaxone) while minimizing the risk of adverse reactions or medication incompatibilities.