What is the next step in management for a 50-year-old patient (fifty-year-old patient) with testicular pain presenting to the Emergency Department (ED) and found to have a scrotolith (scrotal lithiasis) on scrotal ultrasound?

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Last updated: March 20, 2025View editorial policy

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From the Guidelines

For a 50-year-old male presenting with testicular pain and a scrotolith on ultrasound, the next step in management would be conservative treatment with NSAIDs such as ibuprofen 600mg every 6 hours or naproxen 500mg twice daily for pain relief. The patient should be advised to use scrotal support and apply cold compresses intermittently to reduce discomfort. Scrotal calcifications are typically benign findings that don't require surgical intervention unless they're causing significant symptoms. According to the most recent guidelines, ultrasound is the established first-line imaging modality for acute scrotal disease, and can be used to diagnose most scrotal disorders when combined with clinical history and physical examination 1.

Key Considerations

  • The patient's symptoms and physical examination should be carefully evaluated to rule out other causes of testicular pain such as epididymitis, orchitis, or testicular torsion.
  • Laboratory tests including urinalysis, urine culture, and CBC should be considered if infection is suspected 1.
  • Additional imaging such as a follow-up ultrasound in 4-6 weeks may be considered to ensure stability of the finding.
  • Reassurance should be provided that scrotal calcifications themselves are generally not concerning for malignancy, but regular self-examination of the testicles is still recommended.

Management Approach

  • Conservative management with NSAIDs and scrotal support is the initial approach, with urology consultation considered if pain persists despite conservative measures.
  • The American College of Radiology recommends ultrasound as the initial imaging modality for newly diagnosed palpable scrotal abnormality, with or without a history of trauma or infection 1.
  • It's essential to integrate clinical data, including the presence of fever, waxing and waning pain, and laboratory markers for infection, to distinguish between different entities such as torsion/detorsion and epididymoorchitis 1.

From the Research

Next Steps in Management

The patient presents with testicular pain and a scrotolith on scrotal ultrasound. The next steps in management would involve:

  • Ruling out other causes of testicular pain, such as varicocele, epididymitis, or testicular torsion 2, 3, 4, 5
  • Further evaluation of the scrotolith, as it may be associated with underlying conditions such as testicular microlithiasis, which has been linked to malignant disease 3
  • Consideration of a non-surgical approach, as varicocelectomy is typically reserved for patients with clinically palpable varicocele and persistent pain 2
  • Possible referral to a specialist, such as a urologist, for further evaluation and management 3, 5

Diagnostic Considerations

The diagnosis of scrotal pain can be complex, and it is essential to consider various differential diagnoses, including:

  • Epididymitis, which is a common cause of acute testicular pain in young men 3, 4
  • Testicular torsion, which requires immediate surgical intervention 4, 5
  • Rare differential diagnoses, such as tumors, segmental testicular infarction, and testicular vasculitis 5

Imaging and Evaluation

Ultrasonography is the ideal non-invasive imaging modality for evaluating scrotal abnormalities, including scrotal pain and swelling 6. The use of high-frequency linear array transducers and color and spectral Doppler analysis can provide excellent anatomic detail and assess vascular perfusion 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Varicocele and Testicular Pain: A Review.

The world journal of men's health, 2019

Research

Scrotal pain in the absence of torsion; need for vigilance.

Emergency medicine journal : EMJ, 2003

Research

Ultrasonography of the scrotum in adults.

Ultrasonography (Seoul, Korea), 2016

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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