Carpal Tunnel Syndrome: This condition is a common cause of wrist weakness, numbness, and tingling, especially in individuals who perform repetitive tasks with their hands. The median nerve compression leads to symptoms that can be perceived as wrist weakness.

Radial Neuropathy: Damage to the radial nerve can cause weakness in the wrist and hand, particularly affecting the extensor muscles, leading to difficulty in extending the wrist or fingers.
Ulnar Neuropathy: Compression or damage to the ulnar nerve can result in weakness and clumsiness of the hand, affecting the intrinsic muscles of the hand and potentially perceived as wrist weakness.
Tendinitis or Tenosynovitis: Inflammation of the tendons or their surrounding sheaths in the wrist can cause pain and weakness, especially with movement or specific activities.
Repetitive Strain Injury: Overuse or repetitive strain can lead to inflammation and pain in the wrist, causing subjective weakness.

Acute Compartment Syndrome: A medical emergency where increased pressure within a muscle compartment leads to nerve and muscle damage. Early recognition is crucial to prevent permanent damage.
Neoplastic Conditions: Tumors affecting the nerves or bones of the wrist can cause progressive weakness and other neurological symptoms.
Infections (e.g., Osteomyelitis, Septic Arthritis): Infections in the bones or joints of the wrist can cause severe pain, swelling, and weakness, requiring prompt antibiotic treatment.

Amyotrophic Lateral Sclerosis (ALS): A progressive neurological disease affecting nerve cells in the brain and spinal cord, leading to loss of muscle control. Wrist weakness could be an early symptom in some cases.
Multifocal Motor Neuropathy: A rare condition characterized by asymmetric muscle weakness, often affecting the arms, which could be perceived as wrist weakness.
Plexopathies: Injuries or conditions affecting the brachial plexus can cause a variety of symptoms including weakness in the arm and wrist.