What is the definition of a difficult airway?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 3, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Definition of a Difficult Airway

A difficult airway is defined as a clinical situation in which a physician trained in anesthesia care experiences anticipated or unanticipated difficulty or failure with face-mask ventilation, laryngoscopy, ventilation using a supraglottic airway, tracheal intubation, extubation, or invasive airway. 1

Specific Types of Difficult Airways

Difficult Facemask Ventilation

  • Occurs when it is not possible to provide adequate ventilation (confirmed by end-tidal carbon dioxide detection) due to:
    • Inadequate mask seal
    • Excessive gas leak
    • Excessive resistance to the ingress or egress of gas 1

Difficult Laryngoscopy

  • Defined as inability to visualize any portion of the vocal cords after multiple attempts at laryngoscopy 1
  • May be further subdivided into grades according to the Cormack & Lehane classification, with grade 3 being subdivided into 3a (epiglottis can be lifted) and 3b (epiglottis cannot be lifted from the posterior pharyngeal wall) 1

Difficult Supraglottic Airway Ventilation

  • Occurs when adequate ventilation cannot be provided due to:
    • Difficult supraglottic airway placement
    • Multiple attempts required for placement
    • Inadequate supraglottic airway seal
    • Excessive gas leak
    • Excessive resistance to gas flow 1

Difficult or Failed Tracheal Intubation

  • Defined as either:
    • Tracheal intubation requiring multiple attempts
    • Complete failure of tracheal intubation after multiple attempts 1

Difficult or Failed Tracheal Extubation

  • The loss of airway patency and adequate ventilation after removal of a tracheal tube or supraglottic airway from a patient with a known or suspected difficult airway (an "at risk" extubation) 1

Difficult or Failed Invasive Airway

  • Anatomic features or abnormalities that reduce or prevent the likelihood of successfully placing an airway into the trachea through the front of the neck 1

Signs of Inadequate Ventilation

  • Absent or inadequate exhaled carbon dioxide
  • Absent or inadequate chest movement
  • Absent or inadequate breath sounds
  • Auscultatory signs of severe obstruction
  • Cyanosis
  • Gastric air entry or dilatation
  • Decreasing or inadequate oxygen saturation
  • Absent or inadequate exhaled gas flow as measured by spirometry
  • Anatomic lung abnormalities detected by lung ultrasound
  • Hemodynamic changes associated with hypoxemia or hypercarbia (hypertension, tachycardia, bradycardia, arrhythmia)
  • Changed mental status or somnolence 1

Clinical Application

  • These definitions apply to all airway management and anesthetic care delivered in:
    • Inpatient settings (perioperative, non-operating room, emergency department, critical care)
    • Ambulatory settings (surgery centers, office-based procedures) 1
  • The guidelines are intended for use by anesthesiologists and all others who perform anesthesia care or airway management 1

Important Considerations

  • Difficult airways should be anticipated whenever possible through comprehensive assessment 2
  • The incidence of difficult mask ventilation varies widely (0.08% to 15%) depending on the criteria used 3
  • Predictors of difficult mask ventilation include obesity, age >55 years, history of snoring, lack of teeth, presence of beard, Mallampati Class III or IV, and abnormal mandibular protrusion 3
  • Difficult tracheal intubation is more frequent in patients who experience difficult mask ventilation 3
  • The most critical airway situation, "cannot intubate, cannot oxygenate," occurs rarely (0.0019-0.04%) but can have severe consequences including hypoxic brain damage and death 4

Management Approach

  • Management should follow a structured algorithm with Plans A through D as outlined by airway management societies 1
  • Each plan should be implemented sequentially based on the outcome of the previous plan 1
  • Preparedness for failed intubation and use of adjuncts such as video laryngoscopy, supraglottic airway devices, and awake intubation techniques are essential components of difficult airway management 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Difficult mask ventilation.

Anesthesia and analgesia, 2009

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.