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Last updated: October 4, 2025View editorial policy

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Differential Diagnosis for Abdominal Cocoon Syndrome

Single Most Likely Diagnosis

  • Abdominal cocoon syndrome: This is the most likely diagnosis, as the term "abdominal cocoon syndrome" directly refers to a condition where the small bowel is encapsulated by a fibrotic cocoon-like sac, leading to intestinal obstruction. The presentation of abdominal cocoon syndrome typically includes symptoms of intestinal obstruction such as abdominal pain, nausea, vomiting, and constipation.

Other Likely Diagnoses

  • Internal hernia: This condition can cause similar symptoms of intestinal obstruction and could be considered in the differential diagnosis due to the potential for bowel entrapment and obstruction.
  • Adhesional bowel obstruction: This is a common cause of intestinal obstruction, especially in patients with a history of abdominal surgery, and should be considered due to its prevalence and potential for similar clinical presentation.
  • Intussusception: Although more common in children, intussusception can occur in adults and cause intestinal obstruction, making it a plausible alternative diagnosis.

Do Not Miss Diagnoses

  • Mesenteric ischemia: This is a critical diagnosis to consider because it can lead to bowel infarction and has a high mortality rate if not promptly treated. Symptoms can be similar to those of abdominal cocoon syndrome, including severe abdominal pain.
  • Volvulus: This condition involves the twisting of a portion of the intestine and can cause severe abdominal pain and obstruction. It requires urgent diagnosis and treatment to prevent bowel ischemia and infarction.
  • Closed-loop obstruction: This is a serious condition that can lead to rapid deterioration and requires immediate surgical intervention. It presents with severe abdominal pain and signs of obstruction.

Rare Diagnoses

  • Sclerosing encapsulating peritonitis: This is a rare condition that can cause abdominal pain and intestinal obstruction due to the formation of a thick, fibrotic membrane around the intestines.
  • Abdominal lymphoma: Although rare, lymphoma can cause intestinal obstruction and should be considered in the differential diagnosis, especially in patients with systemic symptoms or a history of lymphoma.
  • Intra-abdominal fibromatosis: This rare condition involves the growth of fibrous tissue within the abdomen, which can lead to intestinal obstruction and other complications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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