What is the recommended adult dose of Augmentin (amoxicillin-clavulanate) 875-125?

Recommended Adult Dosage of Augmentin 875-125

For adults, the recommended dosage of Augmentin (amoxicillin-clavulanate) 875-125 mg is one tablet every 12 hours. 1

Dosing Guidelines

• The standard adult dose of Augmentin 875-125 mg is one tablet every 12 hours (twice daily) 1
• For more severe infections, particularly respiratory tract infections, this twice-daily dosing is appropriate and effective 1, 2
• Augmentin should be taken at the start of a meal to enhance absorption of clavulanic acid and minimize potential gastrointestinal intolerance 1
• The total daily dose provides 1750 mg of amoxicillin and 250 mg of clavulanic acid when taken as directed 1, 3

Dosing in Special Populations

• Renal impairment:

  • Patients with severe renal impairment (glomerular filtration rate <30 mL/min) should not receive the 875-125 mg formulation 1
  • For patients with GFR 10-30 mL/min: Use 500-125 mg or 250-125 mg every 12 hours, depending on infection severity 1
  • For patients with GFR <10 mL/min: Use 500-125 mg or 250-125 mg every 24 hours 1
  • Hemodialysis patients should receive an additional dose both during and at the end of dialysis 1

• Hepatic impairment:

  • Patients with hepatic impairment should be dosed with caution and require regular monitoring of hepatic function 1

Clinical Applications

• Augmentin 875-125 mg is commonly used for:
  • Respiratory tract infections 2
  • Skin and soft tissue infections 4
  • Urinary tract infections 5
  • As part of treatment for chronic carriers of Group A Streptococcus (40 mg amoxicillin/kg/day in three doses) 4

Important Considerations

• The 875-125 mg formulation should not be substituted with two 500-125 mg tablets or two 250-125 mg tablets, as the clavulanic acid component would be doubled 1
• Peak serum levels of amoxicillin (approximately 11.23 μg/mL) occur about 2 hours after administration 3
• Augmentin 875-125 mg maintains adequate tissue concentrations in respiratory tract tissues, making it effective for respiratory infections 2, 3
• Common adverse effects include gastrointestinal disturbances such as diarrhea, nausea, and vomiting 1, 6

Common Pitfalls to Avoid

• Avoid using in patients with a history of penicillin allergy or serious hypersensitivity reactions to penicillins or cephalosporins 1
• Do not double the clavulanic acid component by using multiple lower-dose tablets to achieve the 875 mg amoxicillin dose 1
• Ensure adequate hydration during treatment, especially in patients with renal impairment 1
• Monitor for signs of superinfection or Clostridium difficile-associated diarrhea during treatment 1