What is the significance of a homogeneous ANA (Antinuclear Antibody) titer of 1:640?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 10, 2025 • View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Significance of Homogeneous ANA Titer of 1:640

  • A homogeneous ANA titer of 1:640 is significant in the diagnosis of systemic autoimmune rheumatic diseases (SARDs) 1.
  • Studies have shown that ANA titration and pattern are helpful in the diagnosis of SARDs, with a homogeneous pattern being significantly associated with SARDs 1.
  • The assessment of nuclear staining on ANCA-neutrophils can help to stratify nuclear homogeneous patterns on ANA-HEp-2 cells and determine whether the ANA pattern is attributed to DFS70 Abs, which can be found in healthy individuals, especially in young individuals 2.
  • A study found that ANA titration of equal or more than 1:320 can be used as the best titration for differentiating between SARDs and non-SARDs in a positive ANA sample, with a sensitivity and specificity of 86.7% and 77.6%, respectively 1.
  • Another study found that a homogeneous staining pattern was an additional risk factor for autoimmune diseases in ANA-positive patients, with an odds ratio of 4.562 (95% CI: 3.076-6.766, p < 0.001) 3.
  • The prevalence and clinical significance of rare antinuclear antibody patterns, including homogeneous patterns, are not well understood, but studies suggest that they may be associated with autoimmune liver disease or carcinoma 4.
  • The association between anti-double stranded antibody and ANA titers and fluorescence patterns in systemic lupus erythematosus (SLE) has been investigated, with results showing that anti-dsDNA antibodies are often detected at ANA titers of 1:640 and beyond 5.

References

Related Questions

What is the next step for a patient with a homogeneous Antinuclear Antibody (ANA) titer of 1:640?
What is the interpretation of an Antinuclear Antibody (ANA) titer of 1:80 with a nuclear, homogeneous pattern and Actin less than 20?
Is a homogeneous antinuclear antibody (ANA) pattern seen in extractable nuclear antigen (ENA) negative patients?
What are the next steps for a patient with a high Antinuclear Antibody (ANA) titer of 1:640, homogenous pattern, normal kidney and liver function, significant fatigue, hair loss, and elevated thyroid antibodies, indicating potential autoimmune thyroiditis and systemic lupus erythematosus (SLE) symptoms?
What follow-up testing is required for a patient with a positive Antinuclear Antibody (ANA) test and a homogeneous nuclear pattern?
Where would an Upper Motor Neuron (UMN) spine lesion be located in a 24-year-old trans man with a family history of Multiple Sclerosis (MS), presenting with positive Babinski sign, heavy leg feeling, intentional tremor of hands, weakness of fingers, preserved vision, and full body muscle tics, with no lesions in the brain, C1, C2, C3, or C4, and experiencing numbness and sharp pain in the right hand and forearm upon ulnar flossing exercise?
Where would an Upper Motor Neuron (UMN) spine lesion be located in a 24-year-old trans man with a family history of Multiple Sclerosis (MS), presenting with positive Babinski sign, heavy leg feeling, intentional tremor of hands, weakness of fingers, preserved vision, and full body muscle tics, with no lesions in the brain, C1, C2, C3, or C4, and experiencing numbness and sharp pain in the right hand and forearm upon ulnar flossing exercise?
What is the diagnosis for a new hematoma on the leg?
What is the appropriate evaluation for a new leg hematoma?
What causes elevated hemoglobin (Hgb), hematocrit (Hct), and mean corpuscular volume (MCV) in a patient with pneumonia?
What is the next step for a patient with a homogeneous Antinuclear Antibody (ANA) titer of 1:640?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.

Ask Question