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Last updated: October 5, 2025View editorial policy

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Differential Diagnosis for SIBO and Abdominal Pain

  • Single most likely diagnosis
    • Small Intestine Bacterial Overgrowth (SIBO): This is the most likely diagnosis given the symptoms of SIBO and abdominal pain, as SIBO is a condition characterized by an excessive growth of bacteria in the small intestine, leading to abdominal pain, bloating, and other gastrointestinal symptoms.
  • Other Likely diagnoses
    • Irritable Bowel Syndrome (IBS): IBS is a common condition that can cause abdominal pain, bloating, and changes in bowel habits, and it often co-exists with SIBO.
    • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause abdominal pain, diarrhea, and weight loss, and may be considered in the differential diagnosis.
    • Gastroesophageal Reflux Disease (GERD): GERD can cause abdominal pain, bloating, and discomfort, especially after eating.
  • Do Not Miss diagnoses
    • Intestinal obstruction: Although less likely, intestinal obstruction can cause severe abdominal pain and is a medical emergency that requires prompt attention.
    • Appendicitis: Appendicitis is a serious condition that can cause abdominal pain, nausea, and vomiting, and requires immediate medical attention.
    • Mesenteric ischemia: This is a rare but life-threatening condition that can cause severe abdominal pain, and is often associated with atherosclerosis or blood clots.
  • Rare diagnoses
    • Celiac disease: An autoimmune disorder that causes the immune system to react to gluten, leading to abdominal pain, diarrhea, and malabsorption.
    • Whipple's disease: A rare bacterial infection that can cause abdominal pain, diarrhea, and weight loss.
    • Eosinophilic gastroenteritis: A rare condition characterized by an accumulation of eosinophils in the gastrointestinal tract, leading to abdominal pain, nausea, and vomiting.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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