Differential Diagnosis for Pain at the Middle of the Ball of the Foot with a Palpable Nodule
- Single Most Likely Diagnosis
- Morton's neuroma: This condition is characterized by a benign growth of nerve tissue in the ball of the foot, often between the third and fourth toes, which can cause pain and a palpable nodule in the affected area. The symptoms described match closely with those of Morton's neuroma, making it the most likely diagnosis.
- Other Likely Diagnoses
- Intermetatarsal bursitis: Inflammation of the bursae between the metatarsal bones can cause pain and swelling in the ball of the foot, potentially leading to a palpable nodule. This condition can mimic the symptoms of Morton's neuroma.
- Metatarsalgia: This term refers to pain in the ball of the foot, which can be caused by various factors, including poor foot mechanics, overuse, or ill-fitting shoes. While it might not always present with a palpable nodule, it's a common condition affecting the same area.
- Sesamoiditis: Inflammation of the tendons surrounding the sesamoid bones, which are located beneath the first metatarsal bone, can cause pain in the ball of the foot. A palpable nodule could be present if there's significant swelling or if a sesamoid bone is fractured.
- Do Not Miss Diagnoses
- Osteoid osteoma: A small, benign bone tumor that can cause severe pain, often worse at night, and can be associated with a palpable nodule if it occurs in the bones of the foot. Although rare, missing this diagnosis could lead to prolonged pain and disability.
- Ewing's sarcoma or other bone cancers: While extremely rare, these conditions can present with pain and swelling in the foot, including the formation of a palpable nodule. Early diagnosis is crucial for effective treatment.
- Rare Diagnoses
- Ganglion cyst: A non-cancerous lump that can develop on the foot, including the ball area, due to a herniation of a joint or tendon capsule. It might cause pain and could be mistaken for a nodule.
- Plantar fibroma: A benign growth on the plantar fascia, which can cause pain and a palpable lump in the arch or ball of the foot. It's less common than other conditions listed but should be considered in the differential diagnosis.