Platelet-Rich Fibrin (PRF) for Under-Eye Rejuvenation
PRF is highly recommended for periorbital rejuvenation due to its demonstrated safety profile and effectiveness in improving skin condition around the eyes, including reduction of wrinkles, hyperpigmentation, and enhancement of overall skin freshness. 1
Benefits of PRF for Under-Eye Treatment
- PRF has shown promising outcomes for periorbital rejuvenation with excellent safety profile and long-term improvements in skin condition 1
- Treatment results in noticeable improvement in deep and fine wrinkles, periocular hyperpigmentation, and overall skin freshness in the under-eye area 2
- PRF increases skin thickness (up to 1.6 times) as measured by high-frequency ultrasound devices 2
- As an autologous material derived from the patient's own blood, PRF has fewer safety concerns compared to chemical fillers that many practitioners avoid in the periorbital region 1
Recommended Administration Technique
- For optimal safety in the delicate periorbital area, use small gauge needles (30G) for intradermal injection 2, 1
- When using microneedling devices, set depth to 0.25mm to avoid damaging the thin skin around the eyes 1
- If using the Alb-PRF formulation, a 22G × 2 inches (~5 cm) cannula is recommended for enhanced safety around the eyes 2
- Multiple treatment sessions are typically needed, with treatments spaced approximately 2-4 weeks apart for optimal results 2
Patient Counseling Points
- Warn patients about potential side effects including bruising and swelling, which are common but temporary when treating the periorbital area 1
- Inform patients that multiple sessions may be required to achieve optimal results 2
- Explain that PRF offers a natural alternative to chemical fillers with lower risk of adverse reactions 1
- Results are not permanent but can provide significant improvement in skin quality and appearance 2
Advantages Over Other Treatment Options
- PRF offers a safer profile compared to chemical fillers, which carry risks of vascular occlusion, granulomas, or migration 1
- Unlike botulinum toxin injections that primarily address dynamic wrinkles, PRF improves overall skin quality, thickness, and addresses static wrinkles 2
- PRF can be used in combination with other treatments for enhanced results, though more research is needed on these combinations 1
Limitations and Considerations
- While PRF shows promising results, larger controlled studies are still needed to determine optimal administration protocols 2, 1
- Results may vary between patients based on individual factors such as age, skin quality, and severity of periorbital concerns 1
- The periorbital area remains challenging to treat due to its thin skin, constant blinking motion, and proximity to the eye 2