Adderall and Progesterone Concurrent Use
Yes, Adderall (amphetamine and dextroamphetamine) and progesterone can be taken concurrently as there are no documented significant drug interactions between these medications. 1, 2, 3
Adderall Information
- Adderall XR is typically started at 10 mg once daily in the morning for adults with ADHD, with dose titration occurring in 5 mg weekly increments up to a maximum of 50 mg daily 1, 3
- Adderall should be administered in the morning to minimize sleep disturbances 3
- Adderall (amphetamine mixed salts) does not appear to be associated with major congenital malformations or significant adverse developmental outcomes when used therapeutically 1
- Monitoring for side effects such as irritability, insomnia, and cardiovascular effects is recommended when taking Adderall 1, 4
Progesterone Information
- Progesterone is commonly used in hormone replacement therapy for conditions such as premature ovarian insufficiency 1
- Micronized progesterone (MP) is often the first choice among progestins due to its lower risk of cardiovascular disease and venous thromboembolism compared to synthetic progestins 1
- Progesterone can be administered orally, vaginally, or transdermally, with typical doses ranging from 200-300 mg daily when used cyclically 1
Interaction Considerations
- There is no evidence in the clinical guidelines suggesting contraindications or significant interactions between Adderall and progesterone 1, 2, 3
- Some research suggests that progesterone may actually attenuate (reduce) the subjective effects of stimulants like Adderall, which could potentially reduce the efficacy of Adderall 5
- A study examining the role of hormones in modulating stimulant effects found that progesterone administration may reduce the positive subjective effects of stimulants 5
Monitoring Recommendations
- When taking both medications concurrently, it is important to monitor for:
- Regular assessment of therapeutic effects and side effects is recommended when taking either medication 3
Special Considerations
- If using progesterone for hormone replacement therapy alongside Adderall, the timing of administration may be optimized by taking Adderall in the morning and progesterone in the evening to minimize potential interactions 1, 3
- For women with ADHD who are also using progesterone for contraception or hormone replacement, be aware that progesterone might slightly reduce the subjective effects of Adderall 5
- When using transdermal forms of both hormones and stimulants, absorption mechanisms may be similar, but this doesn't constitute a contraindication 6