What is the treatment for contact dermatitis?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 21, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

The treatment for contact dermatitis should primarily involve topical steroids and topical tacrolimus, as supported by recent guidelines 1. When managing contact dermatitis, it is essential to identify and avoid the triggering substance.

  • For mild cases, over-the-counter treatments such as calamine lotion, hydrocortisone cream (1%), or antihistamines like diphenhydramine (Benadryl) 25-50mg every 4-6 hours for itching can be used.
  • For moderate cases, prescription-strength topical corticosteroids such as triamcinolone 0.1% applied twice daily for 1-2 weeks may be necessary, as well as topical tacrolimus, which has been shown to be effective in the treatment of contact dermatitis 1.
  • Severe or widespread cases might require second-line treatments including phototherapy and systemic immunomodulators such as methotrexate and mycophenolate mofetil, as recommended by the British Association of Dermatologists' guidelines for the management of contact dermatitis 2017 1. It is also crucial to moisturize regularly with fragrance-free products to help repair the skin barrier and keep the affected area clean but avoid hot water and harsh soaps.
  • Replacement of soaps and detergents with emollients is useful, even if they are not the cause of the dermatitis, as they are irritants which will compound the situation, as noted in the guidelines 1.
  • Substitution of different materials both in the workplace and outside can help avoid the implicated allergen or irritant, such as using thiuram-free gloves or changing biocides in industrial coolant oils 1.

From the Research

Treatment Options for Contact Dermatitis

The treatment for contact dermatitis primarily involves avoiding the offending agent [(2,3,4)]. However, in cases where avoidance is not possible, various therapeutic options are available to manage the condition.

  • Topical Treatments: Topical corticosteroids are commonly used to reduce inflammation and alleviate symptoms [(2,3)].
  • Systemic Treatments: In severe cases of allergic contact dermatitis, systemic therapeutic agents such as cyclosporine may be used 5.
  • Emollients and Skin Care: Restoring the skin barrier and reducing inflammation through the use of emollients, antihistamines, and other topical treatments is also important 3.
  • Avoidance and Protection: Eliminating the offending agent and protecting the skin from further exposure is crucial in both diagnosis and management [(2,3,4)].

Management of Specific Types of Contact Dermatitis

Different types of contact dermatitis, such as irritant contact dermatitis and allergic contact dermatitis, may require distinct management approaches.

  • Irritant Contact Dermatitis: The diagnosis is generally based on clinical appearance, history, and diagnostic patch testing to rule out an allergic component 4.
  • Allergic Contact Dermatitis: Systemic treatments and immunomodulatory agents may be necessary in severe cases 5.

Additional Considerations

It is essential to note that the treatment of contact dermatitis should be tailored to the individual patient's needs and the specific characteristics of the condition [(2,3)].

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Contact Dermatitis: Classifications and Management.

Clinical reviews in allergy & immunology, 2021

Research

Systemic Treatments for Allergic Contact Dermatitis.

Dermatitis : contact, atopic, occupational, drug, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.