Differential Diagnosis for Lower Extremity Swelling
- Single Most Likely Diagnosis + Chronic Venous Insufficiency: This is often the most common cause of lower extremity swelling, especially in patients with a history of deep vein thrombosis, varicose veins, or long periods of standing. It leads to fluid accumulation due to the veins' inability to return blood to the heart efficiently.
- Other Likely Diagnoses + Heart Failure: Swelling in the lower extremities can be a sign of right-sided heart failure, where the heart is not pumping efficiently, leading to fluid buildup. + Renal Failure: Decreased kidney function can lead to fluid retention, causing swelling in the lower extremities. + Lymphedema: This condition involves the blockage of lymph vessels, which can lead to swelling, usually in one extremity. + Cellulitis or Infection: Bacterial infections of the skin can cause swelling, redness, and warmth in the affected area.
- Do Not Miss Diagnoses + Deep Vein Thrombosis (DVT): Although not the most common cause, DVT is a critical diagnosis to consider due to its potential for pulmonary embolism, which can be life-threatening. + Compartment Syndrome: A condition where pressure within the muscles builds to dangerous levels, reducing blood flow and potentially leading to muscle and nerve damage. + Pulmonary Embolism (in the context of DVT): While not directly causing swelling, it's a potential consequence of DVT and can be fatal.
- Rare Diagnoses + Pseudolymphoma: A rare condition that mimics lymphoma but is not cancerous, can cause swelling among other symptoms. + Filariasis: A parasitic infection that can cause lymphedema, more common in tropical regions. + Sarcoidosis: An autoimmune disease that can affect various parts of the body, including the lymph nodes, potentially leading to swelling. + Fabry Disease: A genetic disorder that can lead to the accumulation of a particular type of fat in the body's cells, affecting many parts of the body and potentially causing swelling.