From the Research
There is no direct evidence that ferritin can increase DHEA levels in the body, as they are two distinct biological compounds with different functions. Ferritin primarily stores iron and releases it in a controlled fashion, while DHEA is a hormone precursor that can be converted to testosterone and estrogen. Iron status and hormonal regulation operate through separate physiological pathways.
Key Points to Consider
- The most recent and highest quality study on DHEA is from 2021 1, which investigated the effect of vitamin D and DHEA combination therapy on thyroid autoimmunity in euthyroid women with autoimmune thyroiditis.
- This study found that vitamin D/DHEA combination therapy decreased serum titres of thyroid peroxidase and thyroglobulin antibodies, and slightly decreased thyrotropin levels, as well as increased DHEA-S and testosterone levels.
- However, this study does not provide evidence for a direct relationship between ferritin and DHEA levels.
- Other studies have investigated the effects of DHEA supplementation on various health outcomes, including adrenal insufficiency 2, systemic lupus erythematosus 3, and depressive disorders 3.
- These studies suggest that DHEA may have beneficial effects on well-being, fatigue, and disease activity in certain populations, but do not provide evidence for a relationship between ferritin and DHEA levels.
Recommendations
- If you're concerned about low DHEA levels, appropriate interventions would include DHEA supplements (typically 25-50mg daily for women and 50-100mg daily for men), though these should only be taken under medical supervision.
- Lifestyle factors like adequate sleep, stress management, and regular exercise may naturally support adrenal hormone production.
- If you're experiencing symptoms of hormonal imbalance, it's best to consult with a healthcare provider who can test your hormone levels and recommend appropriate treatment rather than assuming a connection between ferritin and DHEA.