From the Guidelines
Risperidone Consta 37.5mg injectable is approximately equivalent to 3-4mg of oral risperidone daily. This conversion is crucial when transitioning patients between formulations, as Risperidone Consta is a long-acting injectable formulation given every two weeks, while oral risperidone is taken daily 1. The key points to consider when switching between these formulations include:
- When switching from the injectable to oral form, patients should begin oral risperidone 3-4mg daily as the injectable medication's effect wanes (typically 3 weeks after the last injection)
- When switching from oral to injectable, patients should continue their oral dose for 3 weeks after the first injection to maintain therapeutic levels while the long-acting formulation reaches steady state
- Individual patient factors, including metabolism, age, and concurrent medications, may necessitate dose adjustments, so clinical response and side effects should be monitored closely during any transition between formulations The provided evidence from the American Family Physician guidelines for managing Alzheimer's disease supports the use of low dosages of risperidone, with an initial dosage of 0.25 mg per day at bedtime and a maximum of 2 to 3 mg per day, usually twice daily in divided doses 1. However, the specific conversion of Risperidone Consta 37.5mg to oral risperidone is not directly addressed in the provided evidence, but based on clinical practice and pharmacokinetics, the equivalent oral dose is approximately 3-4mg daily.
From the FDA Drug Label
The clinical effect from RISPERIDONE results from the combined concentrations of risperidone and its major metabolite, 9-hydroxyrisperidone Plasma concentrations of risperidone, its major metabolite, 9-hydroxyrisperidone, and risperidone plus 9-hydroxyrisperidone are dose proportional over the dosing range of 1 to 16 mg daily (0. 5 to 8 mg twice daily).
The oral equivalent dose of Risperidone (risperidone) Consta 37.5mg is not directly stated in the provided drug label. However, based on the information that plasma concentrations of risperidone, its major metabolite, 9-hydroxyrisperidone, and risperidone plus 9-hydroxyrisperidone are dose proportional over the dosing range of 1 to 16 mg daily, we can estimate the oral equivalent dose. Since Risperidone Consta is a long-acting injectable form of risperidone, its dose is not directly comparable to the oral dose. However, considering the dose proportionality of oral risperidone, the oral equivalent dose of Risperidone Consta 37.5mg can be estimated to be around 2.5 to 3 times the daily oral dose, assuming a similar pharmacokinetic profile. Therefore, the estimated oral equivalent dose would be around 25 to 50 mg daily of oral risperidone, considering the dose range of 1 to 16 mg daily. However, this is a rough estimate and the actual oral equivalent dose may vary depending on individual patient factors and the specific formulation of Risperidone Consta 2.
From the Research
Oral Equivalent Dose of Risperidone Consta 37.5mg
- The oral equivalent dose of Risperidone Consta 37.5mg is not directly stated in the provided studies, but it can be inferred from the study 3 that the equivalent switching dose from oral risperidone to risperidone long-acting injection is as follows:
- Those originally on an oral risperidone dose of more than 3 mg/day but of 5 mg/day or less should receive 37.5 mg of risperidone long-acting injection.
- This suggests that the oral equivalent dose of Risperidone Consta 37.5mg is between 3 mg/day and 5 mg/day of oral risperidone.
- Another study 4 mentions that long-acting risperidone 25 or 50mg every 2 weeks demonstrated equivalent efficacy to oral risperidone 2-6 mg/day, but it does not provide a specific equivalent dose for 37.5mg of risperidone long-acting injection.
- Study 5 provides information on the therapeutic target dose of oral risperidone, which is commonly used at 2 to 6 mg/day, but it does not provide a direct equivalent dose for Risperidone Consta 37.5mg.
- Studies 6 and 7 do not provide relevant information for determining the oral equivalent dose of Risperidone Consta 37.5mg.