What is the recommended dosage of Evion (Vitamin E) tablets for adults?

Recommended Dosage of Evion (Vitamin E) Tablets for Adults

For healthy adults, the recommended daily dosage of Evion (Vitamin E) is 15 mg (approximately 22.5 IU) per day, with supplementation of up to 200 mg (approximately 300 IU) per day being safe and potentially beneficial for specific conditions. 1

Standard Dosage Recommendations

• The Dietary Reference Intake (DRI) for vitamin E for adult men and women is set at a Recommended Dietary Allowance (RDA) of 15 mg α-tocopherol per day 1
• European Food Safety Authority (EFSA) recommends an Adequate Intake (AI) of 13 mg/day for men and 11 mg/day for women 1
• For enteral nutrition, at least 15 mg α-tocopherol per day with 1500 kcal is recommended (Grade A recommendation with 100% consensus) 1

Therapeutic Dosages for Specific Conditions

• For patients with vitamin E deficiency (plasma α-tocopherol levels below 12 μmol/L), supplementation should start with 100 mg per day 1
• For long-standing fat malabsorption (e.g., short bowel syndrome), 200 mg/day is recommended to improve neurological symptoms 1
• For immune function enhancement in older adults, 200 IU/day (approximately 134 mg) has shown benefits without adverse effects 1

Safety Profile and Upper Limits

• The Tolerable Upper Limit (UL) for adults is set at 1000 mg (2325 μmol) of any form of supplementary α-tocopherol 1
• Vitamin E is considered safe even at large supplemental oral doses up to 3200 IU per day with no consistent adverse effects 1, 2
• Doses ≤400 IU/day have shown no effect on all-cause mortality, and dosages <150 IU/day may slightly decrease mortality 1
• Clinical trials support that vitamin E supplements appear safe for most adults in amounts ≤1600 IU (1073 mg RRR-α-tocopherol or equivalent) 3

Precautions and Contraindications

• High doses of vitamin E may induce bleeding risks by decreasing γ-carboxylation of prothrombin 1
• Individuals taking anticoagulant drugs like warfarin or those who are vitamin K deficient should not take vitamin E supplements without medical supervision 1, 2
• High levels of vitamin E intake are contraindicated in subjects receiving vitamin K antagonists as anticoagulant therapy 4, 2

Monitoring

• Vitamin E status should be determined when there is clinical suspicion of deficiency, particularly in conditions such as cystic fibrosis, α-beta lipoproteinemia, and thrombotic thrombocytopenic purpura (TTP) 1
• In the absence of clinical signs of deficiency, there is no indication to measure vitamin E status 1
• When measuring vitamin E levels, it is recommended to express them as a ratio to lipids (cholesterol and triglycerides) for accurate assessment 1

Conversion Information

• 1 IU of natural vitamin E (d-α-tocopherol) = 0.67 mg RRR-α-tocopherol 1
• 1 IU of synthetic vitamin E (dl-α-tocopherol) = 0.45 mg all-rac-α-tocopherol 1

Vitamin E deficiency is rare and typically appears in the context of severe malnutrition or fat malabsorption disorders. Early vitamin E inadequacy in adults with fat malabsorption is generally asymptomatic, but prolonged deficiency can lead to neurological symptoms including balance and coordination disorders, peripheral neuropathy, and muscle weakness 1.