What is the recommended tube size in grams for clotrimazole (antifungal medication) cream?

Recommended Tube Size for Clotrimazole Cream

For clotrimazole cream, the standard tube size is 21 grams (0.74 oz) for a complete treatment course. 1

Clotrimazole Formulations and Packaging

• Clotrimazole 1% cream typically comes in a 21-gram tube with applicators for a 7-14 day treatment course 2
• Clotrimazole 2% cream comes in a 21-gram tube with three disposable applicators for a 3-day treatment course 1
• The tube size is standardized to provide sufficient medication for a complete treatment course based on the concentration and recommended duration of therapy 2

Treatment Recommendations by Condition

For Vulvovaginal Candidiasis:

• For uncomplicated vulvovaginal candidiasis:

  • Clotrimazole 1% cream: 5g intravaginally for 7-14 days 2
  • Clotrimazole 2% cream: 5g intravaginally for 3 days 2
  • Clotrimazole vaginal tablets are also available in 100mg and 500mg strengths as alternatives 2

• For complicated vulvovaginal candidiasis:

  • Longer duration of therapy (10-14 days) with topical clotrimazole is recommended 2
  • For recurrent infections, maintenance therapy may be needed, with options including clotrimazole cream 200mg twice weekly 2

For Cutaneous Fungal Infections:

• For dermatophyte infections (tinea cruris, tinea corporis):
  • Apply clotrimazole 1% cream to affected areas twice daily for 4 weeks 3, 4
  • Clotrimazole 1% powder is an effective alternative for intertriginous areas 5, 4

Clinical Considerations

• The 21-gram tube size is designed to provide sufficient medication for a complete treatment course for most indications 1
• For extensive infections or longer treatment courses, multiple tubes may be required
• Clotrimazole cream is oil-based and may weaken latex condoms and diaphragms 2
• For oropharyngeal candidiasis, clotrimazole troches (lozenges) are used rather than cream formulations 2

Treatment Efficacy

• Topical clotrimazole cream results in relief of symptoms and negative cultures in 80-90% of patients who complete therapy for vulvovaginal candidiasis 2
• Clotrimazole 1% cream applied for 7 days has shown a 75% success rate in treating vulvovaginal candidiasis 6
• For tinea cruris, clotrimazole 1% cream applied for 4 weeks demonstrates significant improvement in erythema, scaling, and itching 3