From the Research
N-acetylcysteine (NAC) is not directly mentioned in the provided studies as a cause of xerostomia (dry mouth). However, based on the available evidence, it is essential to consider the potential effects of various medications on salivary glands and oral health. The study by 1 discusses the impact of anticholinergic medications on salivary glands, leading to dry mouth, but does not mention NAC. Another study by 2 reviews treatment strategies for xerostomia, including the use of pilocarpine and malic acid, but does not address NAC. The study by 3 examines the side effects of psychotropic drugs on oral health, including dry mouth, but focuses on anticholinergic and antiadrenergic effects, not NAC. The meta-analysis by 4 investigates the risk of dry mouth associated with second-generation antidepressants, which is not directly related to NAC. Lastly, the review by 5 explores the effect of NAC on biofilms in respiratory tract infections, but does not discuss its potential impact on salivary glands or oral health.
Given the lack of direct evidence linking NAC to xerostomia, it is crucial to prioritize the patient's overall health and consider potential interactions between NAC and other medications that may contribute to dry mouth. If a patient experiences persistent dry mouth while taking NAC, staying well-hydrated and using sugar-free lozenges or gum may help alleviate symptoms. Additionally, consulting with a healthcare provider to adjust the dosage or explore alternative supplements may be necessary. It is essential to weigh the benefits and potential risks of NAC and other medications, considering the individual patient's health status and medical history.