From the Research
Eliquis (apixaban) is not typically associated with depression as a common side effect, and there is no strong evidence establishing a direct causal relationship between this blood thinner and depression. While some patients taking Eliquis have reported mood changes, the mechanisms of blood thinners like Eliquis primarily involve inhibiting clotting factors in the blood, which do not directly affect brain neurotransmitters that regulate mood 1.
Key Considerations
- The provided evidence does not directly link apixaban with depression, focusing instead on the treatment and mechanisms of depression itself 2, 3, 4, 5, 1.
- Depression is a complex condition influenced by various factors, including underlying health conditions, other medications, and life circumstances 5.
- If a patient taking Eliquis experiences depressive symptoms, it is crucial to discuss these concerns with a healthcare provider to evaluate the cause and determine the best course of action, which may include mental health screening, adjustments to the treatment plan, or referral to a mental health professional 5.
Mechanism and Treatment of Depression
The treatment of depression often involves selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and other anti-inflammatory drugs, which have shown efficacy in reducing depressive symptoms by affecting neuroinflammation and neurotransmitter regulation 3, 4. The choice of treatment depends on the patient's specific condition, response to initial treatment, and the presence of other health issues.
Clinical Approach
Given the lack of direct evidence linking apixaban to depression, the clinical approach should focus on managing the patient's overall health, including their mental health, rather than discontinuing necessary anticoagulant therapy. This involves a comprehensive evaluation of the patient's condition, considering all potential factors contributing to depressive symptoms, and tailoring the treatment plan accordingly 5, 1.