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Last updated: October 7, 2025View editorial policy

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Differential Diagnosis for Swelling and Red Lower Eyelid

  • Single most likely diagnosis
    • Blepharitis: This is an inflammation of the eyelids that can cause redness, swelling, and irritation. It's a common condition and often presents with these symptoms, making it a likely initial diagnosis.
  • Other Likely diagnoses
    • Conjunctivitis: Also known as pink eye, this condition can cause redness and swelling of the eyelid due to infection or allergies.
    • Hordeolum (Stye): A localized infection or inflammation of the eyelid margin involving hair follicles of the eyelashes or meibomian glands, which can cause swelling and redness.
    • Chalazion: A small bump on the eyelid due to a blocked oil gland, which can become inflamed and cause swelling and redness.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital Cellulitis: A serious infection of the tissues surrounding the eye, which can cause swelling, redness, and pain. It requires prompt medical attention to prevent serious complications.
    • Angioedema: A condition characterized by rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues, which can be life-threatening if not treated promptly, especially if it involves the airway.
  • Rare diagnoses
    • Sarcoidosis: A condition that can cause inflammation in various parts of the body, including the eyes, leading to swelling and redness of the eyelids.
    • Granuloma Faciale: A rare skin condition that can cause single or multiple, reddish-brown, indurated plaques or nodules, typically on the face, including the eyelids.
    • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A rare autoimmune disorder that can affect various parts of the body, including the eyes, and cause a range of symptoms including swelling and redness of the eyelids.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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