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Last updated: October 7, 2025View editorial policy

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Differential Diagnosis for Paediatric Patients in Kerala with Fever, Cough, and Quick Onset of Respiratory Distress

Single Most Likely Diagnosis

  • Influenza: Given the symptoms of fever, cough, and quick onset of respiratory distress, influenza is a highly plausible cause, especially during seasonal outbreaks. The rapid progression to respiratory distress suggests a viral pneumonia, which is consistent with influenza.

Other Likely Diagnoses

  • Respiratory Syncytial Virus (RSV) Infection: Common in paediatric patients, RSV can cause severe respiratory illness, including bronchiolitis and pneumonia, especially in young children and infants.
  • Adenoviral Infection: Adenoviruses can cause a range of respiratory illnesses, from mild upper respiratory infections to severe pneumonia, which could explain the symptoms.
  • Pneumococcal Pneumonia: Streptococcus pneumoniae is a common cause of bacterial pneumonia in children, which can present with fever, cough, and respiratory distress.

Do Not Miss Diagnoses

  • COVID-19: Although less common in children, COVID-19 can cause severe respiratory illness and must be considered, especially given its potential for rapid spread and severe outcomes.
  • Tuberculosis (TB): While less likely, TB is a critical diagnosis not to miss, as it requires specific treatment and can have severe consequences if not addressed promptly.
  • Pneumocystis jirovecii Pneumonia: In immunocompromised children, this opportunistic infection can cause severe pneumonia and must be considered to provide appropriate treatment.

Rare Diagnoses

  • Hantavirus Pulmonary Syndrome: Although rare, this viral infection can cause severe respiratory distress and must be considered in the differential diagnosis, especially if there's a history of exposure to rodents or their droppings.
  • Mycoplasma pneumoniae: Typically causing mild infections, Mycoplasma pneumoniae can occasionally lead to severe respiratory illness in children, making it a rare but possible diagnosis.
  • Influenza-associated complications (e.g., secondary bacterial pneumonia, acute respiratory distress syndrome): These complications can significantly worsen the prognosis and require specific management strategies.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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